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The Molecular Biology of Cadherins.

Author: Frans Van Roy
Publisher: San Diego : Elsevier Science, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field. Key features: * Contributions from leading authorities * Informs and updates on all the latest developments in the field.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Van Roy, Frans.
Molecular Biology of Cadherins.
San Diego : Elsevier Science, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Frans Van Roy
ISBN: 9780123946478 0123946476
OCLC Number: 831118387
Notes: 1.4. Evolution of the cadherin superfamily in metazoans.
Description: 1 online resource (513 pages)
Contents: Front Cover; The Molecular Biology of Cadherins; Copyright; Contents; Contributors; Preface; Section A: Cadherins: Molecules and Junctions; Chapter One: Roles of Cadherins and Catenins in Cell-Cell Adhesion and Epithelial Cell Polarity; 1. Introduction: The Basic Design of Polarized Epithelial Cells; 2. Cadherin-Mediated Cell-Cell Adhesion and the Function of Polarity Proteins in Apical-Basal Cell Polarity; 3. Other Functions of E-Cadherin, Catenins, and ``Polarity Protein ́ ́ Complexes in Maintaining Epithelial Homeostasis; 4. Cadherin, Catenins, and the Origins of Epithelial Polarity. AcknowledgmentsReferences; Chapter Two: Stability and Dynamics of Cell-Cell Junctions; 1. Introduction; 2. Stability of AJs; 2.1. Cadherins are organized in molecular clusters at AJs; 2.2. Molecular nature of cadherin-actin interaction; 2.3. Regulation of cadherin cluster stability and mobility; 3. Dynamics of AJs Mediated by Actin Turnover; 3.1. Actin polymerization sustains the establishment and maturation of cell-cell contacts; 3.2. Actin polymerization regulates cadherin endocytosis; 4. Mechanical Regulation of AJs; 4.1. AJs respond to mechanical stimuli. 4.2. Molecular mechanism of mechanosensation by cadherins5. Dynamics of AJs During Development; 5.1. Spatial control of tension; 5.2. Dynamics of actomyosin networks: Pulses and flows; 5.3. Force transmission, cell-cell coordination, and tissue integration; 6. Conclusions; Acknowledgments; References; Chapter Three: Coordinating Rho and Rac: The Regulation of Rho GTPase Signaling and Cadherin Junctions; 1. Introduction; 2. Some Things to Consider About Rho GTPases; 3. Regulation of Rho GTPase Signaling by Classical Cadherins. 3.1. Scenario 1: Activation of signaling in response to cadherin ligation3.1.1. Ligation-induced activation of Rac signaling; 3.1.2. Cadherin-inhibited cell signaling: A key role for GAPs in Rac-Rho cross talk; 3.2. Scenario 2: Cadherins as platforms for coordinating cell signaling; 4. Functions of Rho and Rac in Cadherin Cell-Cell Interactions; 4.1. Cadherins junctions, their actin cytoskeleton and regulation by Rac and Rho; 4.1.1. Junctional actin dynamics; 4.1.2. Contractility at the junctions; 4.2. Effects of GTPase-regulated cytoskeleton on cadherin function. 4.2.1. Cortical organization of cadherins at the cell surface4.2.2. Regulation of cadherin trafficking; 4.2.3. Controlling mechanical forces at cell-cell junctions; 5. Concluding Remarks; Acknowledgments; References; Section B: Versatility of the Cadherin Superfamily; Chapter Four: New Insights into the Evolution of Metazoan Cadherins and Catenins; 1. Cadherins in Multicellular Animals; 1.1. General structure and nomenclature of cadherins; 1.2. The CMB of the cadherin superfamily; 1.3. The cadherin-related major branch of the cadherin superfamily.

Abstract:

Focuses on the research surrounding Cadherins from top experts in the molecular biology. This title informs on all the developments in the field.  Read more...

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