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The molecular biology of Huntington's disease

Author: D C Rubinsztein
Publisher: London : Henry Stewart Talks, 2007.
Series: Henry Stewart talks., Biomedical & life sciences collection., Neurodegenerative diseases : fundamentals, research methods, latest advances.
Edition/Format:   eVideo : Clipart/images/graphics : EnglishView all editions and formats
Database:WorldCat
Summary:
Audio-visual presentation : Clinical presentations of HD ; Pathological features ; Genetic basis ; Trinucleotide repeat expansion mutation ; Huntingtin protein and cell damage ; Abnormal protein aggregation ; Transcriptional abnormalities ; Raised levels of reactive oxygen species ; Future directions for therapeutic intervention ; siRNA approaches ; Induction of autophagy.
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Details

Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: D C Rubinsztein
OCLC Number: 310380813
Notes: Animated audio-visual presentation with synchronized narration.
Description: 1 online resource (1 video file (46 min.)) : sound, color.
Details: System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader 6.0+.
Contents: Clinical presentations of HD --
Pathological features --
Genetic basis --
Trinucleotide repeat expansion mutation --
Huntington protein and cell damage --
Abnormal protein aggregation --
Transcriptional abnormalities --
Raised levels of reactive oxygen species --
Future directions for therapeutic intervention --
siRNA approaches --
Induction of autophagy.
Series Title: Henry Stewart talks., Biomedical & life sciences collection., Neurodegenerative diseases : fundamentals, research methods, latest advances.
Responsibility: David Rubinsztein.
More information:

Abstract:

Audio-visual presentation : Clinical presentations of HD ; Pathological features ; Genetic basis ; Trinucleotide repeat expansion mutation ; Huntingtin protein and cell damage ; Abnormal protein aggregation ; Transcriptional abnormalities ; Raised levels of reactive oxygen species ; Future directions for therapeutic intervention ; siRNA approaches ; Induction of autophagy.

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