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Molecular Biology of the Islets of Langerhans

Author: Hiroshi Okamoto; Cambridge University Press.
Publisher: Cambridge : Cambridge University Press, 1990.
Edition/Format:   eBook : Document : EnglishView all editions and formats

The islets of Langerhans, the primary source of hormone production in the pancreas, have been the focus of research into the nature of diabetes for decades.


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Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Hiroshi Okamoto; Cambridge University Press.
ISBN: 9780511600340 0511600348
OCLC Number: 668199854
Description: 1 online resource (364 pages)
Contents: Preface Hiroshi Okamoto; Introductory overview Hiroshi Okamoto; Part I. The Molecular Biology of Peptide Hormones in the Islets of Langerhans: 1. The organization and structure of insulin genes Graeme I. Bell and Susumu Seino; 2. The regulation of insulin gene expression Michael D. Walker; 3. The translational control of proinsulin synthesis by glucose Nobuyuki Itoh; 4. The structure and regulation of the glucagon gene Joel F. Habener; 5. The structure and regulation of the somatostatin gene Joel F. Habener; 6. The mosaic evolution of the pancreatic polypeptide gene Hiroshi Yamamoto, Hideto Yonekura and Koji Nata; 7. The structure and expression of genes of vasoactive intestinal peptide and related peptides Takashi Yamagami; 8. Pancreastatin: a novel pancreatic hormone Kazuhiko Tatemoto; 9. The processing of peptide precursors Thue W. Schwartz; Part II. Molecular Aspects of Diabetes Mellitus: 10. The molecular basis of experimental diabetes Hiroshi Okamoto; 11. Class II histocompatibility genes and diabetes David Owerbach; 12. The role of the insulin gene in diabetes: use of restriction fragment length polymorphisms in diagnosis Steven C. Elben and M. Alan Permutt; 13. Abnormal products of the human insulin gene Howard S. Tager; 14. A novel gene, rig, activated in insulinomas Shin Takasawa, Chiyoko Inoue, Kiyoto Shiga and Motoo Kitagawa; 16. Defects of signal transduction in a tumoral islet cell line Willy J. Malaisse; Index.
Other Titles: Cambridge books online.
Responsibility: edited by Hiroshi Okamoto.


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"Indisputably this book will provoke a real interest among the endocrinologists, biochemists, molecular biologists and all investigators working in the area of diabetes research." R. Wegmann, Read more...

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