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Molecular biopharmaceutics : aspects of drug characterisation, drug delivery, and dosage form evaluation

Author: Bente Steffansen; Birger Brodin; Carsten Uhd Nielsen
Publisher: London : Pharmaceutical Press, 2010.
Series: ULLA postgraduate pharmacy series.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Focusing on molecular biopharmaceutics, this title presents the study of drug absorption, transport and delivery at the molecular level. It focuses on describing the interplay between chemistry of  Read more...

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Document Type: Book
All Authors / Contributors: Bente Steffansen; Birger Brodin; Carsten Uhd Nielsen
ISBN: 9780853697220 0853697221
OCLC Number: 488979418
Description: xviii, 371 pages : illustrations.
Contents: pt. 1 Introduction --
pt. 2 Physicochemical characterisation of drug candidates --
Acid/base properties, solubility and distribution of drug candidates --
Mechanisms of decomposition of drug candidates --
Kinetics of decomposition in aqueous solution --
Chemical approaches to improving bioavailability properties of oral drug candidates --
Preformulation in the industry step by step --
pt. 3 Membrane transport of drug candidates --
Structure and function of absorption barriers --
Passive diffusion of drug substances: the concepts of flux and permeability --
Carrier-mediated transport kinetics --
Classification of human transporters --
Absorption transporters --
Efflux transporters --
Preclinical evaluation of drug transport --
pt. 4 Describing and predicting bioavailability --
In Vitro dissolution --
The biopharmaceutics classification system in drug discovery and development --
Biosimulation studies.
Series Title: ULLA postgraduate pharmacy series.
Responsibility: edited by Bente Steffansen, Birger Brodin, Carsten Uhd Nielsen.

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