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Molecular genetics of bacteria

Author: Jeremy Dale; Simon Park
Publisher: Chichester, West Sussex, England : Wiley-Blackwell, 2010.
Edition/Format:   eBook : Document : English : 5th edView all editions and formats

* The latest edition of this highly successful introduction tobacterial genetics covering basic concepts and latestdevelopments. * Contains more detail on sigma factors, expanded treatment of  Read more...


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Genre/Form: Electronic books
Additional Physical Format: Print version:
Dale, Jeremy.
Molecular genetics of bacteria.
Chichester, West Sussex, England ; Wiley-Blackwell, 2010
(DLC) 2010287539
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jeremy Dale; Simon Park
ISBN: 9780470710340 0470710349
OCLC Number: 649832597
Description: 1 online resource (xiii, 388 pages) : illustrations
Contents: Preface. <p>1 Nucleic Acid Structure and Function. <p>1.1 Structure of nucleic acids. <p>1.1.1 DNA. <p>1.1.2 RNA. <p>1.1.3 Hydrophobic interactions. <p>1.1.4 Different forms of the double helix. <p>1.1.5 Supercoiling. <p>1.1.6 Denaturation and hybridization. <p>1.1.7 Orientation of nucleic acid strands. <p>1.2 Replication of DNA. <p>1.2.1 Unwinding and rewinding. <p>1.2.2 Fidelity of replication; proofreading. <p>1.3 Chromosome replication and cell division. <p>1.4 DNA repair. <p>1.4.1 Mismatch repair. <p>1.4.2 Excision repair. <p>1.4.3 Recombination (post-replication) repair. <p>1.4.4 SOS repair. <p>1.5 Gene expression. <p>1.5.1 Transcription. <p>1.5.2 Translation. <p>1.5.3 Post-translational events. <p>1.6 Gene organization. <p>2 Mutation and Variation. <p>2.1 Variation and evolution. <p>2.1.1 Fluctuation test. <p>2.1.2 Replica plating. <p>2.1.3 Directed mutation in bacteria? <p>2.2 Types of mutation. <p>2.2.1 Point mutations. <p>2.2.2 Conditional mutants. <p>2.2.3 Variation due to larger-scale DNA alterations. <p>2.2.4 Extrachromosomal agents and horizontal gene transfer. <p>2.3 Recombination. <p>2.3.1 A model of the general (homologous) recombinationprocess. <p>2.3.2 Enzymes involved in recombination. <p>2.4 Phenotypes. <p>2.4.1 Restoration of phenotype. <p>2.5 Mechanisms of mutation. <p>2.5.1 Spontaneous mutation. <p>2.5.2 Chemical mutagens. <p>2.5.3 Ultraviolet irradiation. <p>2.6 Isolation and identification of mutants. <p>2.6.1 Mutation and selection. <p>2.6.2 Replica plating. <p>2.6.3 Isolation of other mutants. <p>2.6.4 Molecular methods. <p>3 Regulation of Gene Expression. <p>3.1 Gene copy number. <p>3.2 Transcriptional control. <p>3.2.1 Promoters. <p>3.2.2 Terminators, attenuators and anti-terminators. <p>3.2.3 Induction and repression: regulatory proteins. <p>3.2.4 Two-component regulatory systems. <p>3.2.5 Global regulatory systems. <p>3.2.6 Quorum sensing. <p>3.3 Translational control. <p>3.3.1 Ribosome binding. <p>3.3.2 Codon usage. <p>3.3.3 Stringent response. <p>3.3.4 Regulatory RNA. <p>3.4 Phase variation. <p>4 Genetics of Bacteriophages. <p>4.1 Bacteriophage structure. <p>4.2 Single-strand DNA bacteriophages. <p>4.2.1 X174. <p>4.2.2 M13. <p>4.3 RNA-containing phages: MS2. <p>4.4 Double-stranded DNA phages. <p>4.4.1 Bacteriophage T4. <p>4.4.2 Bacteriophage . <p>4.4.3 Lytic and lysogenic regulation of bacteriophage . <p>4.5 Restriction and modification. <p>4.6 Bacterial resistance to phage attack. <p>4.7 Complementation and recombination. <p>4.8 Why are bacteriophages important? <p>4.8.1 Phage typing. <p>4.8.2 Phage therapy. <p>4.8.3 Phage display. <p>4.8.4 Phages in the natural environment. <p>4.8.5 Bacterial virulence and phage conversion. <p>5 Plasmids. <p>5.1 Some bacterial characteristics are determined byplasmids. <p>5.1.1 Antibiotic resistance. <p>5.1.2 Colicins and bacteriocins. <p>5.1.3 Virulence determinants. <p>5.1.4 Plasmids in plant-associated bacteria. <p>5.1.5 Metabolic activities. <p>5.2 Molecular properties of plasmids. <p>5.2.1 Plasmid replication and control. <p>5.2.2 Partitioning. <p>5.2.3 Host range. <p>5.2.4 Plasmid incompatibility. <p>5.3 Plasmid stability. <p>5.3.1 Plasmid integrity. <p>5.3.2 Partitioning. <p>5.3.3 Differential growth rate. <p>5.4 Associating a plasmid with a phenotype. <p>6 Gene Transfer. <p>6.1 Transformation. <p>6.2 Conjugation. <p>6.2.1 Mechanism of conjugation. <p>6.2.2 The F plasmid. <p>6.2.3 Conjugation in other bacteria. <p>6.3 Transduction. <p>6.3.1 Specialized transduction. <p>6.4 Recombination. <p>6.4.1 Consequences of recombination. <p>6.4.2 Site-specific and non-homologous (illegitimate)recombination. <p>6.5 Mosaic genes and chromosome plasticity. <p>7 Genomic Plasticity: Movable Genes and PhaseVariation. <p>7.1 Insertion sequences. <p>7.1.1 Structure of insertion sequences. <p>7.1.2 Occurrence of insertion sequences. <p>7.2 Transposons. <p>7.2.1 Structure of transposons. <p>7.2.2 Integrons. <p>7.2.3 ISCR elements. <p>7.3 Mechanisms of transposition. <p>7.3.1 Replicative transposition. <p>7.3.2 Non-replicative (conservative) transposition. <p>7.3.3 Regulation of transposition. <p>7.3.4 Activation of genes by transposable elements. <p>7.3.5 Mu: A transposable bacteriophage. <p>7.3.6 Conjugative transposons. <p>7.4 Phase variation. <p>7.4.1 Variation mediated by simple DNA inversion. <p>7.4.2 Variation mediated by nested DNA inversion. <p>7.4.3 Antigenic variation in the gonococcus. <p>7.4.4 Phase variation by slipped-strand mispairing. <p>7.4.5 Phase variation mediated by differential DNAmethylation. <p>7.5 Clustered regularly interspersed short palindromicrepeats. <p>8 Genetic Modification: Exploiting the Potential ofBacteria. <p>8.1 Strain development. <p>8.1.1 Generation of variation. <p>8.1.2 Selection of desired variants. <p>8.2 Overproduction of primary metabolites. <p>8.2.1 Simple pathways. <p>8.2.2 Branched pathways. <p>8.3 Overproduction of secondary metabolites. <p>8.4 Gene cloning. <p>8.4.1 Cutting and joining DNA. <p>8.4.2 Plasmid vectors. <p>8.4.3 Bacteriophage vectors. <p>8.4.4 Cloning larger fragments. <p>8.4.5 Bacteriophage M13 vectors. <p>8.5 Gene libraries. <p>8.5.1 Construction of genomic libraries. <p>8.5.2 Screening a gene library. <p>8.5.3 Cloning PCR products. <p>8.5.4 Construction of a cDNA library. <p>8.6 Products from cloned genes. <p>8.6.1 Expression vectors. <p>8.6.2 Making new genes. <p>8.6.3 Other bacterial hosts. <p>8.6.4 Novel vaccines. <p>8.7 Other uses of gene technology. <p>9 Genetic Methods for Investigating Bacteria. <p>9.1 Metabolic pathways. <p>9.1.1 Complementation. <p>9.1.2 Cross-feeding. <p>9.2 Microbial physiology. <p>9.2.1 Reporter genes. <p>9.2.2 Chromatin immunoprecipitation. <p>9.2.3 Cell division. <p>9.2.4 Motility and chemotaxis. <p>9.2.5 Cell differentiation. <p>9.3 Bacterial virulence. <p>9.3.1 Wide-range mechanisms of bacterial pathogenesis. <p>9.3.2 Detection of virulence genes. <p>9.4 Specific mutagenesis. <p>9.4.1 Gene replacement. <p>9.4.2 Antisense RNA. <p>9.5 Taxonomy, evolution and epidemiology. <p>9.5.1 Molecular taxonomy. <p>9.5.2 GC content. <p>9.5.3 16 S rRNA. <p>9.5.4 Denaturing-gradient gel electrophoresis andtemperature-gradient gel electrophoresis. <p>9.5.5 Diagnostic use of PCR. <p>9.5.6 Molecular epidemiology. <p>10 Gene Mapping to Genomics and Beyond. <p>10.1 Gene mapping. <p>10.1.1 Conjugational analysis. <p>10.1.2 Gene libraries. <p>10.1.3 Restriction mapping and pulsed-field gelelectrophoresis. <p>10.2 DNA sequence determination. <p>10.2.1 Sanger sequencing. <p>10.2.2 Dye terminator sequencing. <p>10.2.3 Pyrosequencing. <p>10.2.4 Massively parallel sequencing. <p>10.3 Genome sequencing. <p>10.3.1 Genome-sequencing strategies. <p>10.3.2 Relating sequence to function. <p>10.3.3 Metagenomics. <p>10.4 Comparative genomics. <p>10.4.1 Microarrays. <p>10.5 Analysis of gene expression. <p>10.5.1 Transcriptional analysis. <p>10.5.2 Translational analysis. <p>10.6 Metabolomics. <p>10.7 Systems biology and synthetic genomics. <p>10.7.1 Systems biology. <p>10.7.2 Synthetic genomics. <p>10.8 Conclusion. <p>Appendix A Further Reading. <p>Appendix B Abbreviations Used. <p>Appendix C Glossary. <p>Appendix D Enzymes and other Proteins. <p>Appendix E Genes. <p>Appendix F Standard Genetic Code. <p>Appendix G Bacterial Species. <p>Index.
Responsibility: Jeremy W. Dale and Simon Park.


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"This update of a popular textbook provides the latest informationand techniques used to study bacterial genetics. It providesdescriptive information, experimental methods, and cleardescriptions of Read more...

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