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Molecular genetics of inflammatory bowel disease

Autor: Mauro D'Amato; John D Rioux
Editora: New York : Springer, 2013.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the  Ler mais...
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Gênero/Forma: Electronic books
Formato Físico Adicional: Print version:
D'Amato, Mauro.
Molecular Genetics of Inflammatory Bowel Disease.
Dordrecht : Springer, ©2013
Tipo de Material: Documento, Recurso Internet
Tipo de Documento: Recurso Internet, Arquivo de Computador
Todos os Autores / Contribuintes: Mauro D'Amato; John D Rioux
ISBN: 9781461482567 1461482569
Número OCLC: 861337247
Notas: Includes index.
Descrição: 1 online resource (xiii, 343 pages) : color illustrations
Conteúdos: Part I: The Foundation of IBD Genetics, Human and Animal Studies. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges / Xinjun Cindy Zhu and Richard P. MacDermott --
Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies / Jonas Halfvarson --
Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease / Emiko Mizoguchi, Atsushi Mizoguchi and Atul K. Bhan --
Part II: The Genetic and Molecular Makeup of Inflammatory Bowel Disease. Complex Disease Genes and Their Discovery / Jeffrey C. Barrett and Mark J. Daly --
The Genetics of Crohn's Disease / Andre Franke and Miles Parkes --
Genetics of Ulcerative Colitis / Mauro D'Amato, Catherine Labbé and John D. Rioux --
Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases / Charlie W. Lees and Alexandra Zhernakova --
Molecular Profiling of IBD Subtypes/Response to Therapy / Isabelle Cleynen and Séverine Vermeire --
Epigenetics of Inflammatory Bowel Disease / Robert Häsler, Stefan Schreiber and Stephan Beck --
Part III: Pathogenetic Pathways in Inflammatory Bowel Disease. Nod1 and Nod2 and the Immune Response to Bacteria / Maria Kaparakis-Liaskos, Dana J. Philpott --
The IL23-Th17 Axis in Intestinal Inflammation / Kevin J. Maloy --
Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics / Natalia B. Nedelsky, Petric Kuballa and Adam B. Castoreno --
The Epithelial Barrier / Stefan Koch, Asma Nusrat and Charles A. Parkos --
Host Interactions with Bacteria: From "Entente Cordiale" to "Casus Belli" / Nouara Lhocine and Philippe J. Sansonetti --
Cytokines in Inflammatory Bowel Disease / Matthias A. Engel and Markus F. Neurath --
Part IV: Concluding Remarks and Future Perspectives. Towards Personalized Therapy in Inflammatory Bowel Disease / Dermot P.B. McGovern.
Responsabilidade: Mauro D'Amato, John D. Rioux, editors.
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