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Molecular genetics of stroke

Author: Yoshiji Yamada
Publisher: San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, ©2012.
Series: Colloquium digital library of life sciences.; Colloquium series on genomic and molecular medicine, # 1.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Yamada, Yoshiji.
Molecular genetics of stroke.
[S.l.] : Morgan & Claypool, 2012
(OCoLC)793167056
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Yoshiji Yamada
ISBN: 9781615043712 1615043713
OCLC Number: 787601701
Description: 1 online resource (x, 82 pages) : illustrations.
Contents: 1. Introduction. 2. Genetics of stroke. 3. Single-gene disorders associated with stroke. 4. Genetics of common forms of stroke --
4.1 Strategies for genetic analysis of stroke --
4.2 Molecular pathophysiology of ischemic stroke --
4.3 Molecular genetics of ischemic stroke --
4.3.1 Phosphodiesterase 4D, cAMP-specific gene (PDE4D) --
4.3.2 Arachidonate 5-lipoxygenase-activating protein gene (ALOX5AP) --
4.3.3 CDKN2B antisense RNA 1 gene (CDKN2B-AS1) --
4.3.4 Ninjurin 2 gene (NINJ2) --
4.3.5 Paired-like homeodomain 2 gene (PITX2) and zinc finger homeobox 3 gene (ZFHX3) --
4.4 Molecular pathophysiology of intracerebral hemorrhage --
4.5 Molecular genetics of intracerebral hemorrhage --
4.5.1 Apolipoprotein E gene (APOE) --
4.5.2 Collagen, type IV, alpha 1 gene (COL4A1) --
4.6 Molecular pathophysiology of intracranial aneurysm and subarachnoid hemorrhage --
4.7 Molecular genetics of intracranial aneurysm and subarachnoid hemorrhage --
4.7.1 Elastin gene (ELN) and LIM domain kinase 1 gene (LIMK1) --
4.7.2 Tumor necrosis factor receptor superfamily, member 13b gene (TNFRSF13B) --
4.7.3 Five loci for intracranial aneurysm identified by GWASs. 5. Clinical implications. 6. Conclusion --
References --
Titles of related interest.
Series Title: Colloquium digital library of life sciences.; Colloquium series on genomic and molecular medicine, # 1.
Responsibility: Yoshiji Yamada.
More information:

Abstract:

Stroke is an important clinical problem because of its large contribution to mortality. The main causal and treatable risk factors for stroke include hypertension, diabetes mellitus, dyslipidemia, and smoking. In addition to these risk factors, recent studies have shown the importance of genetic factors and interactions between multiple genes and environmental factors. Genetic linkage analyses of families and sib-pairs as well as candidate gene association studies have implicated several loci and many candidate genes in predisposition to ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Recent genome-wide association studies identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.

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