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The Molecular Mechanism of the Supra-Additive Response of Prostate Cancer to Androgen Ablation and Radiotherapy.

Author: Alan Pollack; M D ANDERSON CANCER CENTER HOUSTON TX.
Publisher: Ft. Belvoir Defense Technical Information Center FEB 2001.
Edition/Format:   Book : EnglishView all editions and formats
Database:WorldCat
Summary:
The investigation pursued here involved the characterization of the molecular changes induced by androgen deprivation (AD) and the potential for these changes to result in a supra-additive interaction with radiation (RT). Molecular markers were measured in human tissue samples, as well as LNCaP cells grown in vitro under different conditions. Another project that was to develop out of this work, but which ended up  Read more...
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Document Type: Book
All Authors / Contributors: Alan Pollack; M D ANDERSON CANCER CENTER HOUSTON TX.
OCLC Number: 227992469
Description: 181 p.

Abstract:

The investigation pursued here involved the characterization of the molecular changes induced by androgen deprivation (AD) and the potential for these changes to result in a supra-additive interaction with radiation (RT). Molecular markers were measured in human tissue samples, as well as LNCaP cells grown in vitro under different conditions. Another project that was to develop out of this work, but which ended up being accelerated because of promising results, was the radiosensitizing effect of gene therapy (GT) using adenoviral- p53 (Ad5-p53).

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