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Molecular mechanisms of tumor cell resistance to chemotherapy : targeted therapies to reverse resistance

Author: Benjamin Bonavida
Publisher: New York, NY : Springer, ©2013.
Series: Resistance to targeted anti-cancer therapeutics, v.1.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Benjamin Bonavida
ISBN: 9781461470700 1461470706 1461470692 9781461470694
OCLC Number: 842142209
Notes: Includes index.
Description: 1 online resource.
Contents: Part I. Mechanism of tumor cell resistance to cytotoxic apoptosis drugs: Innate versus induced 1. Molecular pathway of apoptosis 2. Molecular anti-apoptotic pathways in cancer 3. Genetic mechanisms that regulate resistance 4. Oncogenesis and tumor cell resistance 5. Molecular heterogeneity of various cancers and cancer stem cells in resistance 6. Molecular signature profiles of resistance in cancers Part II. Dominant pathways and gene products that regulate resistance 7. Resistant targets for apoptosis 8. Autocrine and Paracrine factors 9. Oncogenes 10.Tumor micro environment Part III. Selective agents that target resistant mechanisms: Direct and indirect 11. Proteasome inhibitors 12. Chemicals: free and encapsulated in nanoparticles 13. Receptor agonists and antagonists 14. Antibodies
Series Title: Resistance to targeted anti-cancer therapeutics, v.1.
Responsibility: Benjamin Bonavida, editor.
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Abstract:

This book surveys current advances in understanding the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. Developments presented  Read more...

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