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Molecular neurosurgery with targeted toxins

Author: Ronald G Wiley; Douglas A Lappi
Publisher: Totowa, N.J. : Humana Press, ©2005.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
"The use of targeted cytotoxins to make highly selective neural lesions for both experimental and clinical purposes has already provided important animal models for diseases such as Alzheimer's, and holds great promise for research and clinical application to pain. In Molecular Neurosurgery With Targeted Toxins, pioneers in the field describe their hands-on experience with the experimental use of these toxins. The  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Molecular neurosurgery with targeted toxins.
Totowa, N.J. : Humana Press, ©2005
(DLC) 2004016130
(OCoLC)55955455
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ronald G Wiley; Douglas A Lappi
ISBN: 1588291995 9781588291998 159259896X 9781592598960 1280358157 9781280358159
OCLC Number: 61049194
Description: 1 online resource (xi, 311 pages) : illustrations
Contents: Introduction to molecular neurosurgery / Ronald G. Wiley and Douglas A. Lappi --
Ribosome-inactivating proteins / Fiorenzo Stirpe --
Biochemical, physiological, and behavioral characterizations of the cholinergic basal forebrain lesion produced by 192 IgG-saporin / Jerene J. Waite --
Basal forebrain cholinergic lesion by 192 IgG-saporin: a tool to assess the consequences of cortical cholinergic dysfunction in Alzheimers disease / Reinhard Schliebs --
192 IgG-saporin-induced partial cortical cholinergic deafferentation as a model for determining the interactions between brain aging and neurodevelopmental defects in the cortical cholinergic input system / Martin Sarter and John P. Bruno --
Exploring the role of acetylcholine in primate cognition using Me20.4 IgG-saporin / Rosalind M. Ridley and Harry F. Baker --
Cortical cholinergic deafferentation induces A-beta deposition: towards a physiologic animal model of Alzheimer's disease / Thomas G. Beach [and others] --
Chemical dissection of brain glucoregulatory circuitry / Sue Ritter [and others] --
Cardiovascular deficits after lesions of C1 adrenergic neurons with a saporin-based immunotoxin / Patrice G. Guyenet, Ruth L. Stornetta, and Ann M. Schreihofer --
Saporin conjugates and pain / Ronald G. Wiley and Douglas A. Lappi --
The use of saporin conjugates to dissect neurons responsible for sleep and wakefulness / Carlos Blanco-Centurion [and others] --
Isolectin I-B4-mediated cytotoxic targeting of sensory neurons / Lucy Vulchanova and Christopher N. Honda --
B fragment of cholera toxin conjugated to saporin / Peter T. O'hara, Kanwarjit Kelley, and Luc Jasmin.
Responsibility: edited by Ronald G. Wiley and Douglas A. Lappi.
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Abstract:

Gives a treatment of the highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology,  Read more...

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"...a good purchase for most neuroscience and neurology libraries." - Doody's Health Science Book Review Journal

 
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