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Molecular pathogenesis of colorectal cancer

Autor: Kevin M Haigis
Editora: New York : Springer, 2013.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with  Ler mais...
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Detalhes

Gênero/Forma: Electronic books
Formato Físico Adicional: Print version:
Haigis, Kevin M.
Molecular Pathogenesis of Colorectal Cancer
Dordrecht : Springer,c2013
Tipo de Material: Documento, Recurso Internet
Tipo de Documento: Recurso Internet, Arquivo de Computador
Todos os Autores / Contribuintes: Kevin M Haigis
ISBN: 9781461484127 146148412X
Número OCLC: 861080764
Descrição: 1 online resource (319 p.)
Conteúdos: The Genetics of Colorectal Cancer / William Hankey and Joanna Groden --
Molecular Mechanisms of Colorectal Carcinogenesis / Jatin Roper --
The Association Between Inflammation and Colorectal Cancer / Maria José Oliveira and Sérgia Velho --
Importance of the Niche: Wnt Signaling and Stem Cell Plasticity in Intestinal Homeostasis and Disease / Owen J. Sansom and Inke Näthke --
Mutational Activation of KRAS and BRAF in Colorectal Cancer / Katherine H. Pedone and Jennifer L. Sells --
The PI3K Pathway in Colorectal Cancers / Jihye Yun and George Poulogiannis --
TGF-ß Signaling Pathway and Colorectal Cancer / William M. Grady --
The Clinical Significance of Mutations in Colorectal Cancer / Franklin W. Huang --
Colorectal Cancer Genome and Its Implications / Nickolas Papadopoulos --
Copy-Number Alterations in the Colorectal Cancer Genome / Jihun Kim and Adam J. Bass --
Genome-Wide Association Studies in Colorectal Cancer / Ian Tomlinson --
Future Prospects for Leveraging Molecular Information in the Fight Against Colorectal Cancer / Laura B. Kleiman and Kevin M. Haigis.
Responsabilidade: Kevin M. Haigis, editor.

Resumo:

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

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