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Molecular pathogenesis of colorectal cancer

Autor: Kevin M Haigis
Editora: New York : Springer, 2013.
Edição/Formato   e-book : Documento : InglêsVer todas as edições e formatos
Base de Dados:WorldCat
Resumo:
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with  Ler mais...
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Detalhes

Gênero/Forma: Electronic books
Formato Físico Adicional: Print version:
Haigis, Kevin M.
Molecular Pathogenesis of Colorectal Cancer.
Dordrecht : Springer, ©2013
Tipo de Material: Documento, Recurso Internet
Tipo de Documento: Recurso Internet, Arquivo de Computador
Todos os Autores / Contribuintes: Kevin M Haigis
ISBN: 9781461484127 146148412X 1461484111 9781461484110
Número OCLC: 861080764
Descrição: 1 online resource (319 pages)
Conteúdos: The Genetics of Colorectal Cancer / William Hankey and Joanna Groden --
Molecular Mechanisms of Colorectal Carcinogenesis / Jatin Roper --
The Association Between Inflammation and Colorectal Cancer / Maria José Oliveira and Sérgia Velho --
Importance of the Niche: Wnt Signaling and Stem Cell Plasticity in Intestinal Homeostasis and Disease / Owen J. Sansom and Inke Näthke --
Mutational Activation of KRAS and BRAF in Colorectal Cancer / Katherine H. Pedone and Jennifer L. Sells --
The PI3K Pathway in Colorectal Cancers / Jihye Yun and George Poulogiannis --
TGF-ß Signaling Pathway and Colorectal Cancer / William M. Grady --
The Clinical Significance of Mutations in Colorectal Cancer / Franklin W. Huang --
Colorectal Cancer Genome and Its Implications / Nickolas Papadopoulos --
Copy-Number Alterations in the Colorectal Cancer Genome / Jihun Kim and Adam J. Bass --
Genome-Wide Association Studies in Colorectal Cancer / Ian Tomlinson --
Future Prospects for Leveraging Molecular Information in the Fight Against Colorectal Cancer / Laura B. Kleiman and Kevin M. Haigis.
Responsabilidade: Kevin M. Haigis, editor.

Resumo:

This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents  Ler mais...

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