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Molecular pathogenesis of colorectal cancer

著者: Kevin M Haigis
出版商: New York : Springer, 2013.
版本/格式:   电子图书 : 文献 : 英语查看所有的版本和格式
数据库:WorldCat
提要:
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with  再读一些...
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类型/形式: Electronic books
附加的形体格式: Print version:
Haigis, Kevin M.
Molecular Pathogenesis of Colorectal Cancer.
Dordrecht : Springer, ©2013
材料类型: 文献, 互联网资源
文件类型: 互联网资源, 计算机文档
所有的著者/提供者: Kevin M Haigis
ISBN: 9781461484127 146148412X 1461484111 9781461484110
OCLC号码: 861080764
描述: 1 online resource (319 pages)
内容: The Genetics of Colorectal Cancer / William Hankey and Joanna Groden --
Molecular Mechanisms of Colorectal Carcinogenesis / Jatin Roper --
The Association Between Inflammation and Colorectal Cancer / Maria José Oliveira and Sérgia Velho --
Importance of the Niche: Wnt Signaling and Stem Cell Plasticity in Intestinal Homeostasis and Disease / Owen J. Sansom and Inke Näthke --
Mutational Activation of KRAS and BRAF in Colorectal Cancer / Katherine H. Pedone and Jennifer L. Sells --
The PI3K Pathway in Colorectal Cancers / Jihye Yun and George Poulogiannis --
TGF-ß Signaling Pathway and Colorectal Cancer / William M. Grady --
The Clinical Significance of Mutations in Colorectal Cancer / Franklin W. Huang --
Colorectal Cancer Genome and Its Implications / Nickolas Papadopoulos --
Copy-Number Alterations in the Colorectal Cancer Genome / Jihun Kim and Adam J. Bass --
Genome-Wide Association Studies in Colorectal Cancer / Ian Tomlinson --
Future Prospects for Leveraging Molecular Information in the Fight Against Colorectal Cancer / Laura B. Kleiman and Kevin M. Haigis.
责任: Kevin M. Haigis, editor.
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摘要:

This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents  再读一些...

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