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Molecular pathogenesis of colorectal cancer

Author: Kevin M Haigis
Publisher: New York : Springer, [2013]
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents  Read more...

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Document Type: Book
All Authors / Contributors: Kevin M Haigis
ISBN: 9781461484110 1461484111
OCLC Number: 871617628
Description: viii, 336 pages : illustrations, portraits
Contents: Preface.- The Genetics of Colorectal Cancer.- Molecular Mechanisms of Colorectal Carcinogenesis.- The association between inflammation and colorectal cancer.- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease.- Mutational activation of KRAS and BRAF in colorectal cancer.- The PI3K pathway in Colorectal Cancers.- TGF-ss signaling pathway and colorectal cancer.- The Clinical Significance of Mutations in Colorectal Cancer.- Colorectal Cancer Genome and Its Implications.- Copy-Number Alterations in the Colorectal Cancer Genome.- Genome-wide association studies in colorectal cancer.- Future prospects for leveraging molecular information in the fight against colorectal cancer.- Index.
Responsibility: Kevin M. Maigis, editor.
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