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Molecular pathogenesis of colorectal cancer

Autore: Kevin M Haigis
Editore: New York : Springer, ©2013.
Edizione/Formato:   book_printbook : EnglishVedi tutte le edizioni e i formati
Banca dati:WorldCat
Sommario:
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with  Per saperne di più…
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Tipo documento: Book
Tutti gli autori / Collaboratori: Kevin M Haigis
ISBN: 9781461484110 1461484111
Numero OCLC: 857961773
Descrizione: viii, 316 pages : illustrations (some color) ; 24 cm
Contenuti: Preface.- The Genetics of Colorectal Cancer.- Molecular Mechanisms of Colorectal Carcinogenesis.- The association between inflammation and colorectal cancer.- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease.- Mutational activation of KRAS and BRAF in colorectal cancer.- The PI3K pathway in Colorectal Cancers.- TGF-ss signaling pathway and colorectal cancer.- The Clinical Significance of Mutations in Colorectal Cancer.- Colorectal Cancer Genome and Its Implications.- Copy-Number Alterations in the Colorectal Cancer Genome.- Genome-wide association studies in colorectal cancer.- Future prospects for leveraging molecular information in the fight against colorectal cancer.- Index.
Responsabilità: Kevin M. Haigis, editor.

Abstract:

This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents  Per saperne di più…

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