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Molecular Pathogenesis of Colorectal Cancer

Author: Ph D Kevin M Haigis
Publisher: New York, NY : Springer New York : Imprint: Springer, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
For more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular  Read more...
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Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ph D Kevin M Haigis
ISBN: 9781461484110 1461484111 9781461484127 146148412X
OCLC Number: 929592942
Notes: Libros electrónicos descargables.
XCS616-006X.
Description: VIII, 316 p. 30 illus., 29 illus. in color.
Contents: Preface --
The Genetics of Colorectal Cancer --
Molecular Mechanisms of Colorectal Carcinogenesis --
The association between inflammation and colorectal cancer --
Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease --
Mutational activation of KRAS and BRAF in colorectal cancer --
The PI3K pathway in Colorectal Cancers --
TGF-ß signaling pathway and colorectal cancer --
The Clinical Significance of Mutations in Colorectal Cancer --
Colorectal Cancer Genome and Its Implications --
Copy-Number Alterations in the Colorectal Cancer Genome --
Genome-wide association studies in colorectal cancer --
Future prospects for leveraging molecular information in the fight against colorectal cancer --
Index
Responsibility: edited by Kevin M. Haigis, Ph.D.

Abstract:

This book identifies and characterizes targetable oncogenic pathways in colorectal cancer. It explores the current and future prospects for targeting these pathways therapeutically and presents  Read more...

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