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Molecular Targeting in Oncology

Author: Howard L Kaufman; Scott Wadler
Publisher: Totowa, NJ : Humana Press, 2008.
Series: Cancer Drug Discovery and Development
Edition/Format:   eBook : Document : EnglishView all editions and formats

This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly  Read more...


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Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Howard L Kaufman; Scott Wadler
ISBN: 9781597453370 1597453374 9781588295774 158829577X
OCLC Number: 762187944
Notes: Biomedical and Life Sciences (Springer-11642).
Description: 1 online resource (Online-Datei.).
Contents: Table of ContentsSection 1 General Strategies for Molecular Targeting in OncologyChapter 1 The Cell Cycle: Therapeutic Targeting of Cell CycleRegulatory Components and Effector Pathways in CancerChad D. Knights and Richard G. PestellChapter 2 mTOR: Properties and TherapeuticsJohn B. Easton and Peter J. HoughtonChapter 3 Ras/Raf/MEK InhibitorsJoseph A. SparanoChapter 4 17AAG: Targeting the Molecular Chaperone Heat Shock Protein 90Len Neckers and Percy IvyChapter 5 The Cancer Epigenome: Can it be targeted for therapy?Sam Thiagalingam and Douglas V. FallerSection 2 Molecular Targeting for Specific Disease SitesChapter 6 Molecular targeting in upper gastrointestinal malignanciesScott WadlerChapter 7 Molecular Targeting of Colorectal Cancer: An Idea Whose TimeHas ComeMark L. Sundermeyer, Alfonso Bellacosa, and Neal J. MeropolChapter 8 Molecular Targeting in Hepatocellular CarcinomaJonathan D. Schwartz. and Josep M. LlovetChapter 9 Molecularly Targeted Therapy in Pancreatic CancerAnupama Goel and Peter KozuchChapter 10 Untargeted Use of Targeted Therapy: A Dilemma in Non-SmallCell Lung CancerCheryl Ho, Angela M. Davies, Primo N. Lara, O. Gautschi, P.C. Mack,Paul H. Gumerlock and David R. GandaraChapter 11 Molecular Targeting in Oncology: Renal Cell CancerOlwen Hahn and Walter StadlerChapter 12 Targeted Therapies for Prostate CancerElisabeth I. Heath and Michael A. CarducciChapter 13 Molecular Targets in Ovarian Cancer and Endometrial CancerNilofer S. Azad, Gisele Sarosy, and Elise C. KohnChapter 14 Targeted Therapy for Breast CancerDeena M. Atieh and Linda T. VahdatChapter 15 MelanomaAkshay Gupta and John M. KirkwoodSection 3 Classes of Drugs for Molecular Targeting in OncologyChapter 16 Antibody Therapy of CancerHossein Borghaei, Liat Binyamin, Igor Astsaturov, and Louis M. WeinerChapter 17 Nucleic Acid Therapies for Cancer TreatmentDan T. Vogl and Alan M. GewirtzChapter 18 Engineering Oncolytic Measles Viruses for Targeted CancerTherapyTakafumi Nakamura and Stephen J. RussellChapter 19 Vaccines as Targeted Cancer TherapyMiguel-Angel Perales, Jedd D. Wolchok and Howard L. KaufmanChapter 20 Cytokine based therapy for cancerHenry B. Koon and Michael B. AtkinsChapter 21 Cyclooxygenase-2 (Cox-2) as a Target for Cancer Preventionand TreatmentMonica Bertagnolli, Jaye L. Viner, and Ernest T. HawkSection 4 Specific Drugs for Molecular Targeting in OncologyChapter 22 Imatinib Mesylate (Gleevec) and the emergence ofchemotherapeutic drug-resistant mutationGerald V. DenisChapter 23 Development of a Targeted Treatment for Cancer: The Exampleof C225 (Cetuximab)John MendelsohnChapter 24 VEGF Inhibition for Cancer TherapyShermini Saini and Herbert HurwitzChapter 25 Somatostatin analogue therapyManish C. Champaneria, M.D., Irvin M. Modlin, M.D., Ph.D., D.Sc., IgorLatich, M.D., Jan Bornschein, Ignat Drozdov, Mark Kidd, Ph.D.Section 5 Challenges in Molecular Targeting in OncologyChapter 26 Patient Selection for Rational Development of NovelAnticancer AgentsGrace K. Dy and Alex A. AdjeiChapter 27 Clinical Trial Design with Targeted AgentsSarita Dubey and Joan H. SchillerChapter 28 How to define treatment success or failure if tumors don'tshrink: Consequences for trial design.JJEM Kitzen, MJA de Jonge, and J VerweijChapter 29 Molecular Imaging in OncologyLalitha Shankar, Anne Menkens, and Daniel C. SullivanChapter 30 Combinations of Molecular Targeted Therapies - Opportunitiesand ChallengesHelen X. Chen and Janet E. DanceyChapter 31 Preclinical Development of Molecularly Targeted Agents
Series Title: Cancer Drug Discovery and Development
Responsibility: edited by Howard L. Kaufman, Scott Wadler, Karen Antman.


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