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Molecular Targets and Strategies in Cancer Prevention.

Author: Malay Chatterjee
Publisher: Cham : Springer International Publishing, 2016.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are highlighted to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Chatterjee, Malay.
Molecular Targets and Strategies in Cancer Prevention.
Cham : Springer International Publishing, ©2016
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Malay Chatterjee
ISBN: 9783319312545 3319312545 9783319312521 3319312529
OCLC Number: 952247906
Notes: 1.1 Diagnosis of Tumor Beyond the Sensitivity Threshold of Current Methods.
Description: 1 online resource (182 pages)
Contents: Strategies to Target Pancreatic Cancer; 1 Introduction; 2 Genetics of Pancreatic Cancer; 2.1 Hereditary/Familial Pancreatic Cancer; 2.2 Signature Mutations Found in Sporadic Pancreatic Cancer; 2.3 Inherited Mutations That Increase the Risk of Developing Pancreatic Cancer; 3 Biomarkers for Detecting Pancreatic Cancer at an Early Stage; 3.1 Circulating Tumor Cells as Markers for Early Detection and Progression; 3.2 Cell-Free Circulating Tumor DNA as Marker for Early Detection; 3.3 Profiling of Micro RNAs as a Method for Early Detection and Response to Treatment. 4 Drug Resistance and Desmoplasia in Pancreatic Cancer4.1 Drug Resistance Due to Regulation of ABC and HENT1 Transporters; 4.2 Drug Resistance Due to Insensitivity to Cell Death; 4.3 Drug Resistance and Recurrence Due to Acquisition of a Stem Cell Phenotype; 4.4 Drug Resistance Caused by Desmoplasia; 5 Summary; References; Microbiota and Chronic Inflammation as Targets for Colorectal Cancer Prevention; 1 Introduction; 2 New Issues in Chemopreventive Studies in Colorectal Cancer Stratifying by Genetic Risk; 3 The CRC Microbiota; 4 Chronic Inflammation and Colorectal Cancer. 4.1 Chronic Inflammation4.2 miRNA and Colorectal Cancer; 5 New Directions; References; Challenges in Multiple Myeloma Chemoprevention: Potential Role of Natural, Synthetic and Endogenous Molecules; 1 Introduction; 2 Basic Principles of Chemoprevention in MM; 3 Phytochemicals; 3.1 Curcumin; 3.2 Resveratrol; 3.3 Chaetocin; 3.4 Guggulsterone; 3.5 Celastrol; 3.6 Thymoquinone; 3.7 Vitamin D; 3.8 Isothiocyanates; 3.9 Epigallocatechin-3-gallate; 3.10 Capsaicin; 3.11 Baicalein; 3.12 Betulinic Acid; 3.13 Butein; 3.14 Gambogic Acid; 4 Antibiotics; 4.1 Mithramycin A; 4.2 Broad Spectrum Antibiotics. 5 Pharmacological Agents5.1 Non-steroidal Anti-inflammatory Drugs (NSAIDs); 5.2 DNMT Inhibitors; 5.3 HDAC Inhibitors; 6 microRNAs; 7 Conclusions; References; Targeting MicroRNAs: Molecular Basis of Cancer Prevention; 1 Introduction; 2 The miRNAs Related to the Exposure to Environmental Factors and Gene Instability During Carcinogenesis; 2.1 Genetic Susceptibility; 2.2 Smoking; 2.3 Radiation; 2.4 Other Factors; 3 The Altered miRNA Expression Profiles of Different Human Cancers; 3.1 Lung Cancer; 3.2 Colon Cancer; 3.3 Prostate Cancer; 3.4 Breast Cancers; 3.5 Pancreatic Cancer; 3.6 Hepatic Cancer. 3.7 Gastric Cancer3.8 Multiple Myeloma; 3.9 Other Tumors; 4 Dietary or Natural Agents Regulate the Expression of miRNAs; 4.1 Regulation of miRNAs by Isoflavone; 4.2 Regulation of miRNAs by Curcumin; 4.3 Regulation of miRNAs by Resveratrol; 4.4 Regulation of miRNAs by Indol-3-carbinol (I3C) and 3,32 Diindolylmethane (DIM); 4.5 Regulation of miRNAs by Vitamins and Other Nutrients; 5 Conclusions and Perspectives; References; The Liquid Biopsies: A New Important Step in Cancer Research; 1 The Tumor Disease and Its Diagnosis: Flying Below the Radar.

Abstract:

The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are highlighted to provide a means and design of future cancer prevention strategies and challenges thereupon. The volume also explores various receptor drugs that are in development process with the emphasis of inhibitors used to prevent malignant gene expression. The book bridges the gap between basic science and clinical application of current knowledge of cancer and emphasizes that tumor progression and cancer metastasis are not random - treatments and cure are logical and eventual. Expertly authored and drawing from a wealth of international perspectives, Molecular Targets and Strategies in Cancer Prevention is invaluable reading for clinicians and researchers in the fields of oncology and molecular biology.

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