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Mouse models for drug discovery : methods and protocols

Author: Gabriele Proetzel; Michael V Wiles
Publisher: Totowa, N.J. : Humana, ©2010.
Series: Methods in molecular biology (Clifton, N.J.), v. 602.; Springer protocols (Series)
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Mouse models for drug discovery.
Totowa, N.J. : Humana, ©2010
(DLC) 2009939644
(OCoLC)503630811
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gabriele Proetzel; Michael V Wiles
ISBN: 9781607610588 1607610582
OCLC Number: 658898958
Description: 1 online resource (xii, 421 pages) : illustrations.
Contents: Improving toxicity screening and drug development by using genetically defined strains / Michael F.W. Festing --
Sophisticated mouse: protecting a precious reagent / Michael V. Wiles, Rob A. Taft --
Genetically engineered mouse models in drug discovery research / Rosalba Sacca, Sandra J. Engle, Wenning Qin, Jeffrey L. Stock, John D. McNeish --
Engineering the mouse genome to model human disease for drug discovery / Frank Koentgen, Gabriele Suess, Dieter Naf --
Profiling of drug action using reporter mice and molecular imaging / Gianpaolo Rando, Andrea Biserni, Paolo Ciana, Adriana Maggi --
Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies / Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule --
Development of novel major histocompatibility complex class I and class II-defecient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease / Steve Pino, Michael A. Brehm, Laurence Covassin-Barberis, Marie King, Bruce Gott, Thomas H. Chase, Jennifer Wagner, Lisa Burzenski, Oded Foreman, Dale L. Greiner, Leonard D. Shultz --
Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type I diabetes in humans / David V. Serreze, Marijke Niens, John Kulik, Teresa P. DeLorenzo --
Mouse models of type II diabetes mellitus in drug discovery / Helene Baribault --
Cholesterol absorption and metabolism / Philip N. Howles --
Collegen-induced arthritis in mice / Lisette Bevaart, Margriet J. Vervoordeldonk, Paul P. Tak --
Skin diseases in laboratory mice: approaches to drug tartget identification and efficacy screening / John P. Sundbert, Kathleen A. Sliva, Caroline McPhee, Lloyd E. King --
Models of metastasis in drug discovery / James E. Talmadge --
Methods for evaluating effects of an ironotecan + 5-fluorouracil/leucovorin (IFL) regimen in an orthotopic metastatic colorectal cancer model utilizing in vivo bioluminescence imaging / David Surguladze, Philipp Steiner, Marie Prewetz, James R. Tonra --
CML mouse model in translational research / Cong Peng, Shaoguang Li --
Mouse models for studying depression-like states and antidepressant drugs / Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, Allan V. Kaleuff --
Virus-delivered RNA interference in mouse brain to study addiction-related behaviors / Amy W. Lasek, Nourredine Azouaou --
Experimental models of anxiety for drug discovery and brain research / Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, Allan v. Kalueff --
Mouse models of neurodegenerative diseases: criteria and general methodology / Christopher Janus, Hans Welzl --
Neuromuscular disease models and analysis / Robert W. Burgess, Gregory A. Cox, Kevin L. Seburn --
Murine model of cutaneous infection with Streptococcus pyogenes / Eva Medina --
Murine model of pneumococcal pneumonia / Eva Medina --
Murine model of polymicrobial septic peritonitis using cecal ligation and puncture (CLP) / Eva Medina.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 602.; Springer protocols (Series)
Responsibility: edited by Gabriele Proetzel and Michael V. Wiles.
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Abstract:

With its versatility, ease of use and similarity to the human genome, the mouse has become a top model for medical study. This book provides background of mice as models and details a collection of  Read more...

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From the reviews: "This book details methods for drug delivery and common measurements using mouse and disease models. ... useful to those who are interested in using mouse models in their research, Read more...

 
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