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Mouse models for drug discovery : methods and protocols

Author: Gabriele Proetzel; Michael V Wiles
Publisher: New York, NY : Humana Press, [2016] ©2016
Series: Methods in molecular biology (Clifton, N.J.), v. 1438.
Edition/Format:   eBook : Document : English : Second editionView all editions and formats
Database:WorldCat
Summary:
With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various  Read more...
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Genre/Form: Electronic books
Laboratory Manuals
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Gabriele Proetzel; Michael V Wiles
ISBN: 9781493936618 1493936611 149393659X 9781493936595
OCLC Number: 949026198
Notes: Includes bibliographical references and index.
Description: 1 online resource (xi, 436 pages) : illustrations (some color).
Contents: Genetically defined strains in drug development and toxicity testing / Michael F.W. Festing - - Simple, efficient CRISPR-Cas9-mediated gene editing in mice : strategies and methods / Benjamin E. Low, Peter M. Kutny, and Michael V. Wiles --
Mouse sperm cryopreservation and recovery of genetically modified mice / Benjamin E. Low, Rob A. Taft, and Michael V. Wiles --
Generation of immunodeficient mice bearing human immune systems by the engraftment of hematopoietic stem cells / Suheyla Hasgur ... [et al.] --
Generation of human liver chimeric mice for the study of human hepatotropic pathogens / Markus von Schaewen, Gabriela Hrebikova, and Alexander Ploss --
Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies / Derry C. Roopenian ... [et al.] --
Humanized mouse model to study human albumin and albumin conjugates pharmacokinetics / Benjamin E. Low and Michael V. Wiles --
Germ-free mice model for studying host-microbial interactions / Yogesh Bhattarai and Purna C. Kashyap --
Bridging mice to men : using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans / David V. Serreze ... [et al.] --
Mouse models of type 2 diabetes mellitus in drug discovery / Helene Baribault --
Cholesterol absorption and metabolism / Philip N. Howles --
Skin diseases in laboratory mice : approaches to drug target identification and efficacy screening / John P. Sundberg ... [et al.] --
Chronic myeloid leukemia (CML) mouse model in translational research / Cong Peng and Shaoguang Li --
Murine model for colitis-associated cancer of the colon / Ashley J. Snider ... [et al.] --
Mouse models for studying depression-like states and antidepressant drugs / Carisa L. Bergner ... [et al.] --
Experimental models of anxiety for drug discovery and brain research / Peter C. Hart ... [et al.] --
Repetitive behavioral assessments for compound screening in mouse models of autism spectrum disorders / Stacey J. Sukoff Rizzo --
Better utilization of mouse models of neurodegenerative diseases in preclinical studies : from the bench to the clinic / Christopher Janus ... [et al.] --
Neuromuscular disease models and analysis / Robert W. Burgess, Gregory A. Cox, and Kevin L. Seburn --
Bright-field imaging and optical coherence tomography of the mouse posterior eye / Mark P. Krebs ... [et al.] --
Mouse models as tools to identify genetic pathways for retinal degeneration, as exemplified by Leber's congenital amaurosis / Bo Chang.
Series Title: Methods in molecular biology (Clifton, N.J.), v. 1438.
Responsibility: edited by Gabriele Proetzel, Michael V. Wiles.
More information:

Abstract:

With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.

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