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Multi-drug resistance in cancer

Author: Jun Zhou
Publisher: New York, N.Y. : Humana Press, ©2010.
Series: Springer protocols (Series); Methods in molecular biology (Clifton, N.J.), v. 596.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
With the devastating complication of cancer cells becoming simultaneously resistant to many structurally and mechanistically unrelated drugs, the efficacy of chemotherapeutic management of cancer often becomes severely limited. In Multi-Drug Resistance in Cancer, leading researchers in the field provide comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Jun Zhou
ISBN: 9781607614166 1607614162
OCLC Number: 476352021
Notes: Title from PDF title page (viewed Dec. 9, 2009).
Description: 1 online resource (xi, 492 pages) : illustrations (some color).
Contents: Multidrug resistance in cancer / Bruce C. Baguley --Multidrug resistance in oncology and beyond : from imaging of drug efflux pumps to cellular drug targets / Wouter B. Nagengast [and others] --
Studying drug resistance using genetically engineered mouse models for breast cancer / Sven Rottenberg, Marina Pajic, and Jos Jonkers --
Mechanisms of multidrug resistance in cancer / Jean-Pierre Gillet and Michael M. Gottesman --
Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells / Anna Maria Calcagno and Suresh V. Ambudkar --
Pharmacogenetics of ATP-binding cassette transporters and clinical implications / Ingolf Cascorbi and Sierk Haenisch --
Flow cytometric evaluation of multidrug resistance proteins / Adorjan Aszalos and Barbara J. Taylor --
Targeted chemotherapy in drug-resistant tumors, noninvasive imaging of P-glycoprotein-mediated functional transport in cancer, and emerging role of pgp in neurodagenerative [sic] diseases / Jothilingam Sivapackiam [and others] --
Epigenetic regulation of multidrug resistance 1 gene expression : profiling CpG methylation status using bisulphite sequencing / Emma K. Baker and Assam El-Osta --
Expression and function of P-glycoprotein in normal tissues : effect on pharmacokinetics / Frantisek Staud [and others] --
Molecular mechanism of ATP-dependent solute transport by multidrug resistance-associated protein 1 / Xiu-bao Chang --
Impact of breast cancer resistance protein on cancer treatment outcomes / Douglas D. Ross and Takeo Nakanishi --
Drug ratio-dependent antagonism : a new category of multidrug resistance and strategies for its circumvention / Troy O. Harasym, Barry D. Liboiron, and Lawrence D. Mayer --
Reversing agents for ATP-binding cassette drug transporters / Chow H. Lee --
Overcoming multidrug resistance in cancer : clinical studies of P-glycoprotein inhibitors / Helen M. Coley --
Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation / Jeannie M. Padowski and Gary M. Pollack --
Examination of CYP3A and P-glycoprotein-mediated drug-drug interactions using animal models / Punit H. Marathe and A. David Rodrigues --
Generating inhibitors of P-glycoprotein : where to, now? / Emily Crowley, Christopher A. McDevitt, and Richard Callaghan --
Immunosuppressors as multidrug resistance reversal agents / Hamid Morjani and Claudie Madoulet --
Overcoming multidrug resistance by RNA interference / Alexandra Stege, Andrea Krühn, and Hermann Lage --
Circumventing tumor resistance to chemotherapy by nanotechnology / Xing-Jie Liang [and others].
Series Title: Springer protocols (Series); Methods in molecular biology (Clifton, N.J.), v. 596.
Responsibility: edited by Jun Zhou.
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Abstract:

The efficacy of chemotherapeutic management of cancer is often severely limited. This book provides comprehensive reviews of multidrug resistance mechanisms. It includes up-to-date techniques for  Read more...

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From the reviews: "This book uses cancer as the focus to discuss both the mechanistic events causing multi-drug resistance and the potential ways to mitigate it. ... In summary, this book provides a Read more...

 
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