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Multiple sclerosis and CNS inflammatory disorders

Author: Lawrence M Samkoff; Andrew D Goodman
Publisher: Chichester, West Sussex, UK : John Wiley & Sons Inc., 2014.
Series: Neurology in practice.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
"Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic disorders. It provides the scientific basis of multiple sclerosis, and its etiology, epidemiology and pathogenesis. It covers the diagnostic process, the course of the disease and prognosis, and the use of MRI in diagnosis and disease monitoring. Disease-modifying  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Multiple sclerosis and CNS inflammatory disorders.
Chichester, West Sussex, UK : John Wiley & Sons Inc., 2014
(DLC) 2014007073
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Lawrence M Samkoff; Andrew D Goodman
ISBN: 9781118298657 1118298659 9781118298664 1118298667 9781118298633 1118298632
OCLC Number: 871228581
Description: 1 online resource.
Contents: ""Title page""; ""Copyright page""; ""Contributors""; ""Series Foreword""; ""Preface""; ""1 Etiology""; ""Background""; ""Genes""; ""Gender effects: Genetic or biologic?""; ""The role of the environment""; ""Combining risk factors""; ""Conclusion""; ""Acknowledgment""; ""References""; ""2 Immunopathogenesis of Multiple Sclerosis""; ""What does the neuropathology of MS tell us about its pathogenesis?""; ""Gray matter pathology""; ""Multiple sclerosis as an autoimmune disease""; ""Candidates for the self-antigen in multiple sclerosis""; ""Antigen spreading""; ""Epitope spreading"" ""Outside-in versus inside-out?""""Lymphocyte trafficking into the CNS""; ""Role of T cells in MS""; ""Role of B cells and humoral immunity""; ""Role of microglia and macrophages""; ""Role of other cells: Dendritic cells and astrocytes""; ""Role of cytokines""; ""What might trigger autoimmunity?""; ""Further Reading""; ""3 Diagnostic Process""; ""Introduction""; ""Clinical features of MS""; ""Diagnostic evaluation of MS""; ""Conclusion""; ""Further Reading""; ""4 MRI in Diagnosis and Disease Monitoring""; ""Introduction""; ""MRI at presentation""; ""MRI diagnostic criteria"" ""MRI consensus protocol""""MRI for monitoring disease and treatment""; ""Limitations""; ""Nonconventional MRI""; ""Conclusions""; ""Acknowledgments""; ""References""; ""5 Relapsing MS: Disease Staging and Therapeutic Algorithms""; ""Introduction""; ""Window""; ""Prognostic factors""; ""Therapy""; ""Initiation""; ""Suboptimal response""; ""Combination therapy""; ""Rescue therapy""; ""Escalation""; ""Rapid advancement""; ""Conclusion""; ""Newer oral agents""; ""Further Reading""; ""6 Progressive MS Treatment Algorithms""; ""Background""; ""Challenges to clinical trials in progressive MS"" ""Clinical trials in progressive MS""""Monitoring progressive MS in clinical practice""; ""Treatment of progressive MS in clinical practice""; ""Stopping disease-modifying therapy""; ""Neuroprotective strategies""; ""Other treatment considerations""; ""Further Reading""; ""7 Sex-Determined Issues in Multiple Sclerosis""; ""Epidemiology of MS and gender""; ""Basic science of sex hormone and chromosome differences seen in MS""; ""Reproductive issues in MS""; ""Pregnancy and the MS patient""; ""Breastfeeding""; ""Female cancers""; ""Male sex hormones and concerns for the male patient"" ""Acknowledgments""""References""; ""8 Pediatric Multiple Sclerosis""; ""Introduction""; ""Definitions""; ""Clinical outcome following a first demyelinating attack""; ""Epidemiology and risk factors""; ""Clinical presentation""; ""Disease course""; ""Diagnostic considerations""; ""Differential diagnosis""; ""Treatment of acute demyelinating attacks""; ""Disease-modifying therapy""; ""Escalation of care for severe MS""; ""Symptomatic therapy""; ""Cognitive dysfunction and quality of life considerations""; ""Conclusions and future directions""; ""Further Reading""
Series Title: Neurology in practice.
Responsibility: edited by Lawrence M. Samkoff, Andrew D. Goodman.
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Abstract:

Multiple Sclerosis and CNS Inflammatory Disorders is a practical guide to effective care of patients with multiple sclerosis and other neuroimmunologic and CNS inflammatory disorders. It provides  Read more...

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