skip to content
Muscle gene therapy : methods and protocols Preview this item
ClosePreview this item
Checking...

Muscle gene therapy : methods and protocols

Author: Dongsheng Duan
Publisher: New York : Humana Press, 2011.
Series: Methods in molecular biology (Clifton, N.J.), volume 709.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body. In Muscle Gene Therapy: Methods and Protocols, expert researchers in the field present a collection of techniques aimed at bridging the translational gap in  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Laboratory Manuals
Additional Physical Format: Print version:
Muscle Gene Therapy.
Springer Verlag 2011
(OCoLC)690089343
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Dongsheng Duan
ISBN: 9781617379826 1617379824
OCLC Number: 700049042
Language Note: English.
Description: 1 online resource (xiii, 382 pages).
Contents: Design and testing of regulatory cassettes for optimal activity in skeletal and cardiac muscles --
Codon optimization of the microdystrophin gene for Duchene muscular dystrophy gene therapy --
Monitoring Duchenne muscular dystrophy gene therapy with epitope-specific monoclonal antibodies --
Methods for noninvasive monitoring of muscle fiber survival with an AAV vector encoding the mSEAP reporter gene --
Monitoring murine skeletal muscle function for muscle gene therapy --
Phenotyping cardiac gene therapy in mice --
Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements --
Directed evolution of adeno-associated virus (AAV) as vector for muscle gene therapy --
Systemic gene transfer to skeletal muscle using reengineered AAV vectors --
Bioinformatic and functional optimization of antisense phosphorodiamidate morpholino oligomers (PMOs) for therapeutic modulation of RNA splicing in muscle --
Engineering exon-skipping vectors expressing U7 snRNA constructs for Duchenne muscular dystrophy gene therapy --
Application of microRNA in cardiac and skeletal muscle disease gene therapy --
Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia --
Lentiviral vector delivery of shRNA into cultured primary myogenic cells: A tool for therapeutic target validation --
Fetal muscle gene therapy/gene delivery in large animals --
Electroporation of plasmid DNA to swine muscle --
Local gene delivery and methods to control immune responses in muscles of normal and dystrophic dogs --
Gene transfer to muscle from the isolated regional circulation --
AAV-mediated gene therapy to the isolated limb in rhesus macaques --
Antisense oligo-mediated multiple exon skipping in a dog model of Duchenne muscular dystrophy --
Whole body skeletal muscle transduction in neonatal dogs with AAV-9 --
A translatable, closed recirculation system for AAV6 vector-mediated myocardial gene delivery in the large animal --
Method of gene delivery in large animal models of cardiovascular diseases --
Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine.
Series Title: Methods in molecular biology (Clifton, N.J.), volume 709.
Responsibility: edited by Dongsheng Duan.

Abstract:

Written in the popular Methods in Molecular Biology (TM) series format, this book presents a collection of techniques aimed at bridging the translational gap in muscle gene therapy between the  Read more...

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/700049042> # Muscle gene therapy : methods and protocols
    a schema:CreativeWork, schema:MediaObject, schema:Book ;
    library:oclcnum "700049042" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nyu> ;
    library:placeOfPublication <http://dbpedia.org/resource/New_York_City> ; # New York
    schema:about <http://dewey.info/class/616.740695/e22/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/3770962258#Topic/muscles_diseases_gene_therapy> ; # Muscles--Diseases--Gene therapy
    schema:about <http://id.worldcat.org/fast/963075> ; # Human genetics
    schema:about <http://id.worldcat.org/fast/939638> ; # Gene therapy
    schema:about <http://experiment.worldcat.org/entity/work/data/3770962258#Topic/muscular_dystrophy_duchenne_genetics> ; # Muscular Dystrophy, Duchenne--genetics
    schema:about <http://id.worldcat.org/fast/809196> ; # Animal genetics
    schema:about <http://experiment.worldcat.org/entity/work/data/3770962258#Topic/muscular_dystrophy_duchenne_therapy> ; # Muscular Dystrophy, Duchenne--therapy
    schema:about <http://id.worldcat.org/fast/1014893> ; # Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/3770962258#Topic/gene_therapy_methods> ; # Gene Therapy--methods
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/272719417> ; # Dongsheng Duan
    schema:datePublished "2011" ;
    schema:description "Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body. In Muscle Gene Therapy: Methods and Protocols, expert researchers in the field present a collection of techniques aimed at bridging the translational gap in muscle gene therapy between the prevalent rodent models and vitally important larger animal models. Divided into three sections, this volume examines basic protocols for optimizing the muscle gene expression cassette and for evaluating the therapeutic outcomes, new developments in muscle gene therapy technology such as adeno-associated viral vector (AAV), oligonucleotide-mediated exon-skipping, and novel RNA-based strategies, and step-by-step guidance on muscle gene delivery in swine, ovine, canine, and non-human primates. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, detailed, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Muscle Gene Therapy: Methods and Protocols serves as an invaluable resource for graduate students, post-doctoral fellows, and principle investigators pursuing the crucial advancement of muscle disease gene therapy in the hope of someday curing these debilitating disorders."@en ;
    schema:description "Design and testing of regulatory cassettes for optimal activity in skeletal and cardiac muscles -- Codon optimization of the microdystrophin gene for Duchene muscular dystrophy gene therapy -- Monitoring Duchenne muscular dystrophy gene therapy with epitope-specific monoclonal antibodies -- Methods for noninvasive monitoring of muscle fiber survival with an AAV vector encoding the mSEAP reporter gene -- Monitoring murine skeletal muscle function for muscle gene therapy -- Phenotyping cardiac gene therapy in mice -- Golden retriever muscular dystrophy (GRMD): Developing and maintaining a colony and physiological functional measurements -- Directed evolution of adeno-associated virus (AAV) as vector for muscle gene therapy -- Systemic gene transfer to skeletal muscle using reengineered AAV vectors -- Bioinformatic and functional optimization of antisense phosphorodiamidate morpholino oligomers (PMOs) for therapeutic modulation of RNA splicing in muscle -- Engineering exon-skipping vectors expressing U7 snRNA constructs for Duchenne muscular dystrophy gene therapy -- Application of microRNA in cardiac and skeletal muscle disease gene therapy -- Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia -- Lentiviral vector delivery of shRNA into cultured primary myogenic cells: A tool for therapeutic target validation -- Fetal muscle gene therapy/gene delivery in large animals -- Electroporation of plasmid DNA to swine muscle -- Local gene delivery and methods to control immune responses in muscles of normal and dystrophic dogs -- Gene transfer to muscle from the isolated regional circulation -- AAV-mediated gene therapy to the isolated limb in rhesus macaques -- Antisense oligo-mediated multiple exon skipping in a dog model of Duchenne muscular dystrophy -- Whole body skeletal muscle transduction in neonatal dogs with AAV-9 -- A translatable, closed recirculation system for AAV6 vector-mediated myocardial gene delivery in the large animal -- Method of gene delivery in large animal models of cardiovascular diseases -- Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/3770962258> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/3770962258#Series/methods_in_molecular_biology_clifton_n_j> ; # Methods in molecular biology (Clifton, N.J.) ;
    schema:isPartOf <http://worldcat.org/issn/1940-6029> ; # Methods in molecular biology,
    schema:isSimilarTo <http://www.worldcat.org/oclc/690089343> ;
    schema:name "Muscle gene therapy : methods and protocols"@en ;
    schema:productID "700049042" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/700049042#PublicationEvent/new_york_humana_press_2011> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/3770962258#Agent/humana_press> ; # Humana Press
    schema:url <https://link.springer.com/openurl?genre=book&isbn=978-1-61737-981-9> ;
    schema:url <http://link.springer.com/10.1007/978-1-61737-982-6> ;
    schema:url <http://link.springer.com/openurl?genre=book&isbn=978-1-61737-981-9> ;
    schema:url <http://link.springer.com/openurl?genre=book&isbn=978-1-61737-982-6> ;
    schema:url <http://dx.doi.org/10.1007/978-1-61737-982-6> ;
    schema:url <http://www.springerprotocols.com/doiresolver?genre=book&pid=10.1007/978-1-61737-982-6> ;
    schema:workExample <http://dx.doi.org/10.1007/978-1-61737-982-6> ;
    schema:workExample <http://worldcat.org/isbn/9781617379826> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/700049042> ;
    .


Related Entities

<http://dbpedia.org/resource/New_York_City> # New York
    a schema:Place ;
    schema:name "New York" ;
    .

<http://experiment.worldcat.org/entity/work/data/3770962258#Series/methods_in_molecular_biology_clifton_n_j> # Methods in molecular biology (Clifton, N.J.) ;
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/700049042> ; # Muscle gene therapy : methods and protocols
    schema:name "Methods in molecular biology (Clifton, N.J.) ;" ;
    .

<http://experiment.worldcat.org/entity/work/data/3770962258#Topic/gene_therapy_methods> # Gene Therapy--methods
    a schema:Intangible ;
    schema:name "Gene Therapy--methods"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/3770962258#Topic/muscular_dystrophy_duchenne_genetics> # Muscular Dystrophy, Duchenne--genetics
    a schema:Intangible ;
    schema:name "Muscular Dystrophy, Duchenne--genetics"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/3770962258#Topic/muscular_dystrophy_duchenne_therapy> # Muscular Dystrophy, Duchenne--therapy
    a schema:Intangible ;
    schema:name "Muscular Dystrophy, Duchenne--therapy"@en ;
    .

<http://id.worldcat.org/fast/1014893> # Medicine
    a schema:Intangible ;
    schema:name "Medicine"@en ;
    .

<http://id.worldcat.org/fast/809196> # Animal genetics
    a schema:Intangible ;
    schema:name "Animal genetics"@en ;
    .

<http://id.worldcat.org/fast/939638> # Gene therapy
    a schema:Intangible ;
    schema:name "Gene therapy"@en ;
    .

<http://id.worldcat.org/fast/963075> # Human genetics
    a schema:Intangible ;
    schema:name "Human genetics"@en ;
    .

<http://viaf.org/viaf/272719417> # Dongsheng Duan
    a schema:Person ;
    schema:familyName "Duan" ;
    schema:givenName "Dongsheng" ;
    schema:name "Dongsheng Duan" ;
    .

<http://worldcat.org/isbn/9781617379826>
    a schema:ProductModel ;
    schema:isbn "1617379824" ;
    schema:isbn "9781617379826" ;
    .

<http://worldcat.org/issn/1940-6029> # Methods in molecular biology,
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/700049042> ; # Muscle gene therapy : methods and protocols
    schema:issn "1940-6029" ;
    schema:name "Methods in molecular biology," ;
    .

<http://www.springerprotocols.com/doiresolver?genre=book&pid=10.1007/978-1-61737-982-6>
    rdfs:comment "An electronic book accessible through the World Wide Web; click for information" ;
    .

<http://www.worldcat.org/oclc/690089343>
    a schema:CreativeWork ;
    rdfs:label "Muscle Gene Therapy." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/700049042> ; # Muscle gene therapy : methods and protocols
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.