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The Na⁺, K⁺ pumps keep us going : how passive and active transport of sodium (Na⁺) and potassium (K⁺) control performance and fatigue in skeletal muscle

Author: Torben Clausen
Publisher: Aarhus, Denmark : Aarhus University Press, 2016.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"Every second throughout life, billions of sodium-potassium pumps enable the human muscle cells to function. The pump is an enzyme found in the plasma membrane of all animal cells and is an important example of active transport. The Na, K⁺-pumps keep us going by pumping sodium out of cells while pumping potassium into cells and without them, we would not survive. Addressed to scientists in the field of biomedicine,  Read more...
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Document Type: Book
All Authors / Contributors: Torben Clausen
ISBN: 9788771249392 8771249397
OCLC Number: 962903012
Description: 120 pages : illustrations (some color), charts (some color) ; 28 cm
Contents: The Na⁺, K⁺ pump and its discovery --
The transport and distribution of Na⁺ and K⁺ in skeletal muscle and how they are quantified --
Rapid passive fluxes of Na⁺ and K⁺ start muscle contraction and set a limit to excitability --
The definition, structure and function of the Na⁺, K⁺-pump --
The synthesis and localization of the Na⁺, K⁺ pumps in skeletal muscle --
Measurements of the content of [³H]ouabain binding sites indicate that in skeletal muscle, the major part of these binding sites of the Na⁺, K⁺ pumps are localized on the outer surface of sarcolemma and in the t-tubules --
The content of Na⁺, K⁺ pumps in skeletal muscles and how it can be quantified --
Muscle contractions, Na⁺, K⁺ transport and sodium potassium fatigue --
The rate of [³H]ouabain binding to sarcolemma can be quantified and what information may this provide? --
Measurements of [³H]ouabain binding to other cell types and preparations --
Acute and long-term regulation of Na⁺, K⁺ pumps in skeletal muscle --
Catecholamines and caffeine --
Peptide hormones stimulating the Na⁺, K⁺ pumps --
Insulin-like growth Factore-I (IGF-I) --
CGRP and other calcitonins --
Amylin, related peptides, and other stimuli for the Na⁺, K⁺ -pumps --
The importance of Na⁺-influx in causing depolarization and muscle fatigue --
Effect of varying Na⁺, K⁺-pump stimulating agents on intracellular Na⁺ in rat soleus muscles and how this may compensate functional defects caused by plasma membrane leakage --
Long-Term regulation of Na⁺, K⁺ pump content --
Training, inactivity and denervation --
Muscular dystrophy and McArdle disease --
Hyperkalemic periodic paralysis in horses, human subjects and mutant mice with a similar geneti anomaly --
K⁺ deficiency and K⁺ restoration --
Thyroid hormones ans starvation --
Thermogenic actions of thyroid hormones and malignant hyperthermia (MH) --
Diabetes --
Steroid hormones, glucocorticoids, aldosterone --
Major conclusions and general perspectives.
Responsibility: by Torben Clausen.

Abstract:

"Every second throughout life, billions of sodium-potassium pumps enable the human muscle cells to function. The pump is an enzyme found in the plasma membrane of all animal cells and is an important example of active transport. The Na, K⁺-pumps keep us going by pumping sodium out of cells while pumping potassium into cells and without them, we would not survive. Addressed to scientists in the field of biomedicine, the author presents a thorough overview of his scientific results over more than 40 years. The book is richly illustrated and seeks to explain how a single molecule creates the required conditions for our muscles to work."

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