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Nadine Dobrovolskaïa-Zavadskaïa and the dawn of developmental genetics
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Nadine Dobrovolskaïa-Zavadskaïa and the dawn of developmental genetics

Author: Vladimir Korzh Affiliation: The Institute of Molecular Agrobiology, National University of Singapore; David Grunwald Affiliation: Department of Human Genetics, University of Utah
Edition/Format: Article Article : English
Publication:BioEssays, v23 n4 (April 2001): 365-371
Other Databases: WorldCatWorldCatWorldCat
Summary:
In one of the first genetic screens aimed at identifying induced developmental mutants, Nadine Dobrovolskaïa-Zavadskaïa, working at the Pasteur Laboratory in the 1920s, isolated and characterized a mutation affecting Brachyury, a gene that regulates tail and axial development in the mouse. Dobrovolskaïa-Zavadskaïa's analysis of Brachyury and other mutations affecting tail development were among the earliest attempts to link gene action with a tissue-specific developmental process in a vertebrate. Her analyses of genes that interacted with Brachyury led to the discovery of the t-haplotype chromosome of mouse. After 70 years, Brachyury and the multiple genes with which it interacts continue to occupy a prominent focus in developmental biology research. A goal of this review is to identify the contributions that Dobrovolskaïa-Zavadskaïa made to our current thinking about Brachyury and how she helped to shape the dawn of the field of developmental genetics. BioEssays 23:365-371, 2001. © 2001 John Wiley & Sons, Inc.  Read more...
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Details

Document Type: Article
All Authors / Contributors: Vladimir Korzh Affiliation: The Institute of Molecular Agrobiology, National University of Singapore; David Grunwald Affiliation: Department of Human Genetics, University of Utah
ISSN:0265-9247
Language Note: English
Unique Identifier: 5152525843
Notes: Number of Figures: 1
Number of References: 74
Number of Words: 1409
Awards:

Abstract:

In one of the first genetic screens aimed at identifying induced developmental mutants, Nadine Dobrovolskaïa-Zavadskaïa, working at the Pasteur Laboratory in the 1920s, isolated and characterized a mutation affecting Brachyury, a gene that regulates tail and axial development in the mouse. Dobrovolskaïa-Zavadskaïa's analysis of Brachyury and other mutations affecting tail development were among the earliest attempts to link gene action with a tissue-specific developmental process in a vertebrate. Her analyses of genes that interacted with Brachyury led to the discovery of the t-haplotype chromosome of mouse. After 70 years, Brachyury and the multiple genes with which it interacts continue to occupy a prominent focus in developmental biology research. A goal of this review is to identify the contributions that Dobrovolskaïa-Zavadskaïa made to our current thinking about Brachyury and how she helped to shape the dawn of the field of developmental genetics. BioEssays 23:365-371, 2001. © 2001 John Wiley & Sons, Inc.

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