skip to content
Nano and cell mechanics : fundamentals and frontiers Preview this item
ClosePreview this item
Checking...

Nano and cell mechanics : fundamentals and frontiers

Author: H D Espinosa; Gang Bao
Publisher: Chichester, West Sussex : John Wiley & Sons, 2013.
Series: Wiley microsystem and nanotechnology series.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

 Read more...

Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Document Type: Book
All Authors / Contributors: H D Espinosa; Gang Bao
ISBN: 9781118460399 1118460391
OCLC Number: 801440772
Description: xxiv, 482 pages : illustrations (some color) ; 25 cm.
Contents: <p>About the Editors xiii <p>List of Contributors xv <p>Foreword xix <p>Series Preface xxi <p>Preface xxiii <p>Part One BIOLOGICAL PHENOMENA <p>1 Cell Receptor Interactions 3 David Lepzelter and Muhammad Zaman <p>1.1 Introduction 3 <p>1.2 Mechanics of Integrins 4 <p>1.3 Two-Dimensional Adhesion 7 <p>1.4 Two-Dimensional Motility 9 <p>1.5 Three-Dimensional Adhesion 11 <p>1.6 Three-Dimensional Motility 12 <p>1.7 Apoptosis and Survival Signaling 13 <p>1.8 Cell Differentiation Signaling 13 <p>1.9 Conclusions 14 <p>References 15 <p>2 Regulatory Mechanisms of Kinesin and Myosin Motor Proteins:Inspiration for Improved Control of Nanomachines 19 Sarah Rice <p>2.1 Introduction 19 <p>2.2 Generalized Mechanism of Cytoskeletal Motors 19 <p>2.3 Switch I: A Controller of Motor Protein and G ProteinActivation 21 <p>2.4 Calcium-Binding Regulators of Myosins and Kinesins 23 <p>2.5 Phospho-Regulation of Kinesin and Myosin Motors 262.6Cooperative Action of Kinesin and Myosin Motors as a Regulator 28 <p>2.7 Conclusion 29 <p>References 30 <p>3 Neuromechanics: The Role of Tension in Neuronal Growth andMemory 35 Wylie W. Ahmed, Jagannathan Rajagopalan, Alireza Tofangchi,and Taher A. Saif <p>3.1 Introduction 35 <p>3.1.1 What is a Neuron? 36 <p>3.1.2 How Does a Neuron Function? 38 <p>3.1.3 How Does a Neuron Grow? 40 <p>3.2 Tension in Neuronal Growth 41 <p>3.2.1 In Vitro Measurements of Tension in Neurons 41 <p>3.2.2 In Vivo Measurements of Tension in Neurons 43 <p>3.2.3 Role of Tension in Structural Development 45 <p>3.3 Tension in Neuron Function 48 <p>3.3.1 Tension Increases Neurotransmission 48 <p>3.3.2 Tension Affects Vesicle Dynamics 48 <p>3.4 Modeling the Mechanical Behavior of Axons 52 <p>3.5 Outlook 58 <p>References 58 <p>Part Two NANOSCALE PHENOMENA <p>4 Fundamentals of Roughness-Induced Superhydrophobicity65 Neelesh A. Patankar <p>4.1 Background and Motivation 65 <p>4.2 Thermodynamic Analysis: Classical Problem (Hydrophobic toSuperhydrophobic) 67 <p>4.2.1 Problem Formulation 68 <p>4.2.2 The Cassie Baxter State 71 <p>4.2.3 Predicting Transition from Cassie Baxter to WenzelState 73 <p>4.2.4 The Apparent Contact Angle of the Drop 77 <p>4.2.5 Modeling Hysteresis 79 <p>4.3 Thermodynamic Analysis: Classical Problem (Hydrophilic toSuperhydrophobic) 84 <p>4.4 Thermodynamic Analysis: Vapor Stabilization 86 <p>4.5 Applications and Future Challenges 90 <p>Acknowledgments 91 <p>References 91 <p>5 Multiscale Experimental Mechanics of HierarchicalCarbon-Based Materials 95 Horacio D. Espinosa, Tobin Filleter, and MohammadNaraghi <p>5.1 Introduction 95 <p>5.2 Multiscale Experimental Tools 97 <p>5.2.1 Revealing Atomic-Level Mechanics: In-Situ TEM Methods98 <p>5.2.2 Measuring Ultralow Forces: AFM Methods 101 <p>5.2.3 Investigating Shear Interactions: In-Situ SEM/AFM Methods102 <p>5.2.4 Collective and Local Behavior: Micromechanical TestingMethods 103 <p>5.3 Hierarchical Carbon-Based Materials 106 <p>5.3.1 Weak Shear Interactions between Adjacent Graphitic Layers106 <p>5.3.2 Cross-linking Adjacent Graphitic Layers 110 <p>5.3.3 Local Mechanical Properties of CNT/Graphene Composites113 <p>5.3.4 High Volume Fraction CNT Fibers and Composites 115 <p>5.4 Concluding Remarks 120 <p>References 123 <p>6 Mechanics of Nanotwinned Hierarchical Metals 129 Xiaoyan Li and Huajian Gao <p>6.1 Introduction and Overview 129 <p>6.1.1 Nanotwinned Materials 130 <p>6.1.2 Numerical Modeling of Nanotwinned Metals 132 <p>6.2 Microstructural Characterization and Mechanical Propertiesof Nanotwinned Materials 134 <p>6.2.1 Structure of Coherent Twin Boundary 134 <p>6.2.2 Microstructures of Nanotwinned Materials 135 <p>6.2.3 Mechanical and Physical Properties of Nanotwinned Metals137 <p>6.3 Deformation Mechanisms in Nanotwinned Metals 145 <p>6.3.1 Interaction between Dislocations and Twin Boundaries146 <p>6.3.2 Strengthening and Softening Mechanisms in NanotwinnedMetals 147 <p>6.3.3 Fracture of Nanotwinned Copper 155 <p>6.4 Concluding Remarks 156 <p>References 157 <p>7 Size-Dependent Strength in Single-Crystalline MetallicNanostructures 163 Julia R. Greer <p>7.1 Introduction 163 <p>7.2 Background 164 <p>7.2.1 Experimental Foundation 164 <p>7.2.2 Models 167 <p>7.3 Sample Fabrication 170 <p>7.3.1 FIB Approach 170 <p>7.3.2 Directional Solidification and Etching 172 <p>7.3.3 Templated Electroplating 173 <p>7.3.4 Nanoimprinting 173 <p>7.3.5 Vapor Liquid Solid Growth 174 <p>7.3.6 Nanowire Growth 175 <p>7.4 Uniaxial Deformation Experiments 175 <p>7.4.1 Nanoindenter-Based Systems (Ex Situ) 176 <p>7.4.2 In-Situ Systems 176 <p>7.5 Discussion and Outlook on Size-Dependent Strength inSingle-Crystalline Metals 178 <p>7.5.1 Cubic Crystals 178 <p>7.5.2 Non-Cubic Single Crystals 183 <p>7.6 Conclusions and Outlook 184 <p>References 185 <p>Part Three EXPERIMENTATION <p>8 In-Situ TEM Electromechanical Testing of Nanowires andNanotubes 193 Horacio D. Espinosa, Rodrigo A. Bernal, and TobinFilleter <p>8.1 Introduction 193 <p>8.1.1 Relevance of Mechanical and Electromechanical Testing forOne-Dimensional Nanostructures 194 <p>8.1.2 Mechanical and Electromechanical Characterization ofNanostructures: The Need for In-Situ TEM 196 <p>8.2 In-Situ TEM Experimental Methods 197 <p>8.2.1 Overview of TEM Specimen Holders 199 <p>8.2.2 Methods for Mechanical and Electromechanical Testing ofNanowires and Nanotubes 200 <p>8.2.3 Sample Preparation for TEM of One-DimensionalNanostructures 208 <p>8.3 Capabilities of In-Situ TEM Applied to One-DimensionalNanostructures 212 <p>8.3.1 HRTEM 212 <p>8.3.2 Diffraction 216 <p>8.3.3 Analytical Techniques 217 <p>8.3.4 In-Situ Specimen Modification 218 <p>8.4 Summary and Outlook 220 <p>Acknowledgments 221 <p>References 221 <p>9 Engineering Nano-Probes for Live-Cell Imaging of GeneExpression 227 Gang Bao, Brian Wile, and Andrew Tsourkas <p>9.1 Introduction 227 <p>9.2 Molecular Probes for RNA Detection 229 <p>9.2.1 Fluorescent Linear Probes 229 <p>9.2.2 Linear FRET Probes 232 <p>9.2.3 Quenched Auto-ligation Probes 233 <p>9.2.4 Molecular Beacons 234 <p>9.2.5 Dual-FRET Molecular Beacons 236 <p>9.2.6 Fluorescent Protein-Based Probes 237 <p>9.3 Probe Design, Imaging, and Biological Issues 239 <p>9.3.1 Specificity of Molecular Beacons 239 <p>9.3.2 Fluorophores, Quenchers, and Signal-to-Background 241 <p>9.3.3 Target Accessibility 242 <p>9.4 Delivery of Molecular Beacons 244 <p>9.4.1 Microinjection 245 <p>9.4.2 Cationic Transfection Agents 245 <p>9.4.3 Electroporation 245 <p>9.4.4 Chemical Permeabilization 246 <p>9.4.5 Cell-Penetrating Peptide 246 <p>9.5 Engineering Challenges and Future Directions 248 <p>Acknowledgments 249 <p>References 249 <p>10 Towards High-Throughput Cell Mechanics Assays for Researchand Clinical Applications 255 David R. Myers, Daniel A. Fletcher, and Wilbur A. Lam <p>10.1 Cell Mechanics Overview 255 <p>10.1.1 Cell Cytoskeleton and Cell-Sensing Overview 256 <p>10.1.2 Forces Applied by Cells 259 <p>10.1.3 Cell Responses to Force and Environment 260 <p>10.1.4 General Principles of Combined Mechanical and BiologicalMeasurements 261 <p>10.2 Bulk Assays 262 <p>10.2.1 Microfiltration 262 <p>10.2.2 Rheometry 264 <p>10.2.3 Ektacytometry 266 <p>10.2.4 Parallel-Plate Flow Chambers 267 <p>10.3 Single-Cell Techniques 268 <p>10.3.1 Micropipette Aspiration 268 <p>10.3.2 Atomic Force Microscopy 270 <p>10.3.3 Microplate Stretcher 272 <p>10.3.4 Optical Tweezers 273 <p>10.4 Existing High-Throughput Cell Mechanical-Based Assays274 <p>10.4.1 Optical Stretchers 274 <p>10.4.2 Traction Force Microscopy via Bead-Embedded Gels 275 <p>10.4.3 Traction Force Microscopy via Micropost Arrays 275 <p>10.4.4 Substrate Stretching Assays 277 <p>10.4.5 Magnetic Twisting Cytometry 277 <p>10.4.6 Microfluidic Pore and Deformation Assays 278 <p>10.5 Cell Mechanical Properties and Diseases 280 <p>References 284 <p>11 Microfabricated Technologies for Cell Mechanics Studies293 Sri Ram K. Vedula, Man C. Leong, and Chwee T. Lim <p>11.1 Introduction 293 <p>11.2 Microfabrication Techniques 294 <p>11.2.1 Photolithography and Soft Lithography 294 <p>11.2.2 Microphotopatterning ( PP) 297 <p>11.3 Applications to Cell Mechanics 298 <p>11.3.1 Micropatterned Substrates 298 <p>11.3.2 Micropillared Substrates 301 <p>11.3.3 Microfluidic Devices 304 <p>11.4 Conclusions 307 <p>References 307 <p>Part Four MODELING <p>12 Atomistic Reaction Pathway Sampling: The Nudged ElasticBandMethod and Nanomechanics Applications 313 Ting Zhu, Ju Li, and Sidney Yip <p>12.1 Introduction 313 <p>12.1.1 Reaction Pathway Sampling in Nanomechanics 314 <p>12.1.2 Extending the Time Scale in Atomistic Simulation 314 <p>12.1.3 Transition-State Theory 315 <p>12.2 The NEB Method for Stress-Driven Problems 315 <p>12.2.1 The NEB method 315 <p>12.2.2 The Free-End NEB Method 317 <p>12.2.3 Stress-Dependent Activation Energy and Activation Volume320 <p>12.2.4 Activation Entropy and Meyer Neldel CompensationRule 322 <p>12.3 Nanomechanics Case Studies 324 <p>12.3.1 Crack Tip Dislocation Emission 324 <p>12.3.2 Stress-Mediated Chemical Reactions 326 <p>12.3.3 Bridging Modeling with Experiment 327 <p>12.3.4 Temperature and Strain-Rate Dependence of DislocationNucleation 329 <p>12.3.5 Size and Loading Effects on Fracture 330 <p>12.4 A Perspective on Microstructure Evolution at Long Times332 <p>12.4.1 Sampling TSP Trajectories 333 <p>12.4.2 Nanomechanics in Problems of Materials Ageing 334 <p>References 336 <p>13 Mechanics of Curvilinear Electronics 339 Shuodao Wang, Jianliang Xiao, Jizhou Song, Yonggang Huang, andJohn A. Rogers <p>13.1 Introduction 339 <p>13.2 Deformation of Elastomeric Transfer Elements duringWrapping Processes 342 <p>13.2.1 Strain Distribution in Stretched Elastomeric TransferElements 342 <p>13.2.2 Deformed Shape of Elastomeric Transfer Elements 344 <p>13.3 Buckling of Interconnect Bridges 347 <p>13.4 Maximum Strain in the Circuit Mesh 351 <p>13.5 Concluding Remarks 355 <p>Acknowledgments 355 <p>References 355 <p>14 Single-Molecule Pulling: Phenomenology and Interpretation359 Ignacio Franco, Mark A. Ratner, and George C. Schatz <p>14.1 Introduction 359 <p>14.2 Force Extension Behavior of Single Molecules 360 <p>14.3 Single-Molecule Thermodynamics 364 <p>14.3.1 Free Energy Profile of the Molecule Plus Cantilever365 <p>14.3.2 Extracting the Molecular Potential of Mean Force ( ) 366 <p>14.3.3 Estimating Force Extension Behavior from ( ) 369 <p>14.4 Modeling Single-Molecule Pulling Using Molecular Dynamics370 <p>14.4.1 Basic Computational Setup 370 <p>14.4.2 Modeling Strategies 371 <p>14.4.3 Examples 373 <p>14.5 Interpretation of Pulling Phenomenology 376 <p>14.5.1 Basic Structure of the Molecular Potential of Mean Force377 <p>14.5.2 Mechanical Instability 378 <p>14.5.3 Dynamical Bistability 381 <p>14.6 Summary 384 <p>Acknowledgments 385 <p>References 385 <p>15 Modeling and Simulation of Hierarchical Protein Materials389 Tristan Giesa, Graham Bratzel, and Markus J. Buehler <p>15.1 Introduction 389 <p>15.2 Computational and Theoretical Tools 391 <p>15.2.1 Molecular Simulation from Chemistry Upwards 391 <p>15.2.2 Mesoscale Methods for Modeling Larger Length and TimeScales 392 <p>15.2.3 Mathematical Approaches to Biomateriomics 394 <p>15.3 Case Studies 400 <p>15.3.1 Atomistic and Mesoscale Protein Folding and Deformationin Spider Silk 400 <p>15.3.2 Coarse-Grained Modeling of Actin Filaments 402 <p>15.3.3 Category Theoretical Abstraction of a Protein Materialand Analogy to an Office Network 403 <p>15.4 Discussion and Conclusion 406 <p>Acknowledgments 406 <p>References 406 <p>16 Geometric Models of Protein Secondary-Structure Formation411 Hendrik Hansen-Goos and Seth Lichter <p>16.1 Introduction 411 <p>16.2 Hydrophobic Effect 412 <p>16.2.1 Variable Hydrogen-Bond Strength 415 <p>16.3 Prior Numerical and Coarse-Grained Models 415 <p>16.4 Geometry-Based Modeling: The Tube Model 416 <p>16.4.1 Motivation 416 <p>16.4.2 Impenetrable Tube Models 417 <p>16.4.3 Including Finite-Sized Particles Surrounding the Protein419 <p>16.4.4 Models Using Real Protein Structure 421 <p>16.5 Morphometric Approach to Solvation Effects 422 <p>16.5.1 Hadwiger s Theorem 422 <p>16.5.2 Applications 424 <p>16.6 Discussion, Conclusions, Future Work 429 <p>16.6.1 Results 429 <p>16.6.2 Discussion and Speculations 430 <p>Acknowledgments 433 <p>References 433 <p>17 Multiscale Modeling for the Vascular Transport ofNanoparticles 437 Shaolie S. Hossain, Adrian M. Kopacz, Yongjie Zhang, Sei-YoungLee, Tae-Rin Lee, Mauro Ferrari, Thomas J.R. Hughes, Wing Kam Liu,and Paolo Decuzzi <p>17.1 Introduction 437 <p>17.2 Modeling the Dynamics of NPs in the Macrocirculation438 <p>17.2.1 The 3D Reconstruction of the Patient-Specific Vasculature439 <p>17.2.2 Modeling the Vascular Flow and Wall Adhesion of NPs440 <p>17.2.3 Modeling NP Transport across the Arterial Wall and DrugRelease 440 <p>17.3 Modeling the NP Dynamics in the Microcirculation 448 <p>17.3.1 Semi-analytical Models for the NP Transport 449 <p>17.3.2 An IFEM for NP and Cell Transport 452 <p>17.4 Conclusions 456 <p>Acknowledgments 456 <p>References 457 <p>Index 461
Series Title: Wiley microsystem and nanotechnology series.
Responsibility: edited by Horacio D. Espinosa, Gang Bao.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

All user tags (1)

View most popular tags as: tag list | tag cloud

Similar Items

Related Subjects:(3)

User lists with this item (3)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


<http://www.worldcat.org/oclc/801440772>
library:oclcnum"801440772"
library:placeOfPublication
library:placeOfPublication
rdf:typeschema:Book
schema:about
schema:about
schema:about
schema:about
schema:contributor
schema:contributor
schema:datePublished"2013"
schema:exampleOfWork<http://worldcat.org/entity/work/id/1169155559>
schema:inLanguage"en"
schema:isPartOf
schema:name"Nano and cell mechanics : fundamentals and frontiers"@en
schema:publication
schema:publisher
schema:workExample
wdrs:describedby

Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.