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NanoCellBiology of secretion : imaging its cellular and molecular underpinnings

Author: Bhanu P Jena; Lloyd L Anderson
Publisher: New York : Springer, 2012.
Series: SpringerBriefs in biological imaging.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:

Understanding live cells at the single molecule level is the most important and single major challenge facing biology and medicine today. Opening with an explanation of Materials and Methods, this  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Jena, Bhanu P.
NanoCellBiology of secretion.
New York : Springer, 2012
(DLC) 2011945438
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Bhanu P Jena; Lloyd L Anderson
ISBN: 9781461424383 1461424380
OCLC Number: 781540178
Description: 1 online resource (xii, 70 pages) : illustrations (chiefly color).
Contents: Understanding live cells at the single molecule level is the most important and single major challenge facing biology and medicine today. Over the past 15 years, there has been a renewed understanding of living cells at the molecular level. Atomic Force Microscopy, Laser Force Microscopy, single secretory vesicle patch clamp studies, highresolution electron microscopy, and x-ray diffraction, are some of the tools now being used to unravel the intricacies of a living cell at the molecular level. Opening with an explanation of Materials and Methods, NanoCellBiology then moves through discussions of porosome discovery, calcium and SNARE-induced fusion, and vesicle swelling before winding up in a final chapter of conclusions and future studies. Succinctly packaged as SpringerBrief, this book is a must for those studying or conducting research in cell biology, biochemistry or nanobiology/nanotechnology. This book will be invaluable to faculty & graduate students involved in Nano Courses; Cell Biology Courses; Biophysics Courses; and Biochemistry Courses as well as practicing Cell Biologists, Biochemists and BioPhysicists. Table of contetns: Introduction.- Materials & Methods.- Porosome Discovery.- Calcium & SNARE-Induced Membrane Fusion.- SNAREs need to reside in opposing membrane.- Membrane curvature dictates SNARE size.- Disassembly of membrane-associated SNARE complex.- CD spectroscopy confirm membrane requirement for t-/v-SNARE assembly.- SNAREs bring opposing bilayers closer for calcium bridging.- Membrane lipids influence SNARE complex assembly-disassembly.- Vesicle swelling and content expulsion during cell secretion.- Secretory vesicle swelling is required for intravesicular content expulsion.- Molecular mechanism of secretory vesicle swelling.- Presence of beta receptors at the secretory vesicle membrane.- Conclusion and future studies.
Series Title: SpringerBriefs in biological imaging.
Other Titles: Nano cell biology of secretion
Responsibility: Bhanu P. Jena ; foreword by Lloyd L. Anderson.
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