skip to content
Natural killer T cells : balancing the regulation of tumor immunity Preview this item
ClosePreview this item
Checking...

Natural killer T cells : balancing the regulation of tumor immunity

Author: Masaki Terabe; Jay A Berzofsky
Publisher: New York, NY : Springer, ©2012.
Series: Cancer drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule.¡ This relatively small but pivotal T cell population bridges the gap between innate and adaptive immunity by rapidly produce large amounts of many kinds of cytokines and by providing the T cell arm of the adaptive immune system a mechanism to  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Natural killer T cells.
New York, NY : Springer, ©2012
(DLC) 2011935528
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Masaki Terabe; Jay A Berzofsky
ISBN: 9781461406136 1461406137
OCLC Number: 757821413
Description: 1 online resource (xi, 205 pages).
Contents: Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi [and others] --
Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg --
Invariant NKT cell-based vaccine strategies / John-Paul Jukes [and others] --
Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe --
The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz --
DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu --
Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth --
NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak --
Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar --
Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders [and others] --
Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama.
Series Title: Cancer drug discovery and development.
Responsibility: Masaki Terabe, Jay A. Berzofsky, editors.

Abstract:

This book reviews what researchers have learned about NKT cells during the last two decades through functional studies in the context of tumor immunology, including clinical trials of NKT cell  Read more...

Reviews

Editorial reviews

Publisher Synopsis

From the reviews:"This book is essentially a collection of reviews that introduce the reader to the wonderful world of iNKT cells, and how their powerful adjuvant properties are being utilised by Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/757821413> # Natural killer T cells : balancing the regulation of tumor immunity
    a schema:MediaObject, schema:Book, schema:CreativeWork ;
    library:oclcnum "757821413" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1009148976#Place/new_york_ny> ; # New York, NY
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/nyu> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Thing/biomedicine> ; # Biomedicine
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/t_cells> ; # T cells
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/tumors_immunological_aspects> ; # Tumors--Immunological aspects
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/killer_cells> ; # Killer cells
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/health_&_fitness_diseases_general> ; # HEALTH & FITNESS--Diseases--General
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_internal_medicine> ; # MEDICAL--Internal Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/immune_tolerance> ; # Immune Tolerance
    schema:about <http://dewey.info/class/616.9940797/e23/> ;
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_diseases> ; # MEDICAL--Diseases
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/cytotoxicity_immunologic> ; # Cytotoxicity, Immunologic
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Thing/medicine> ; # Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Thing/toxicology> ; # Toxicology
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_clinical_medicine> ; # MEDICAL--Clinical Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/natural_killer_t_cells_immunology> ; # Natural Killer T-Cells--immunology
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Thing/cancer_research> ; # Cancer Research
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_evidence_based_medicine> ; # MEDICAL--Evidence-Based Medicine
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Thing/pharmacology_toxicology> ; # Pharmacology/Toxicology
    schema:about <http://id.loc.gov/authorities/subjects/sh85138558> ; # Tumors--Immunological aspects
    schema:about <http://experiment.worldcat.org/entity/work/data/1009148976#Thing/oncology> ; # Oncology
    schema:bookFormat schema:EBook ;
    schema:contributor <http://viaf.org/viaf/223140488> ; # Masaki Terabe
    schema:contributor <http://viaf.org/viaf/75301850> ; # Jay A. Berzofsky
    schema:copyrightYear "2012" ;
    schema:datePublished "2012" ;
    schema:description "Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule.¡ This relatively small but pivotal T cell population bridges the gap between innate and adaptive immunity by rapidly produce large amounts of many kinds of cytokines and by providing the T cell arm of the adaptive immune system a mechanism to detect lipid antigens. NKT cells also have both regulatory and effector functions and have been shown to play critical roles in the regulation of immune responses in many disease settings including cancer. Stimulating the protective functions of NKT cells while inhibiting the negative regulatory activity shows promise for the therapy of cancer and several approaches are in clinical trials. ¡ ¡¡¡¡¡¡¡¡¡¡¡ This book reviews what we have learned about NKT cells during last two decades through functional studies in the context of tumor immunology, including clinical trials of NKT cell targeted therapy.¡ This knowledge should also be informative to understand the role of this underappreciated T cell population in many other fields outside of tumor immunology."@en ;
    schema:description "Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi [and others] -- Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg -- Invariant NKT cell-based vaccine strategies / John-Paul Jukes [and others] -- Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe -- The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz -- DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu -- Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth -- NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak -- Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar -- Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders [and others] -- Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/1009148976> ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://experiment.worldcat.org/entity/work/data/1009148976#Series/cancer_drug_discovery_and_development> ; # Cancer drug discovery and development.
    schema:isSimilarTo <http://worldcat.org/entity/work/data/1009148976#CreativeWork/natural_killer_t_cells> ;
    schema:name "Natural killer T cells : balancing the regulation of tumor immunity"@en ;
    schema:productID "757821413" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/757821413#PublicationEvent/new_york_ny_springer_2012> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/1009148976#Agent/springer> ; # Springer
    schema:url <http://www.myilibrary.com?id=335322> ;
    schema:url <http://site.ebrary.com/id/10499431> ;
    schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=884101> ;
    schema:url <http://dx.doi.org/10.1007/978-1-4614-0613-6> ;
    schema:url <https://grinnell.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4614-0613-6> ;
    schema:url <http://www.myilibrary.com?id=335322&ref=toc> ;
    schema:url <http://link.springer.com/10.1007/978-1-4614-0613-6> ;
    schema:url <http://proxy.library.carleton.ca/login?url=http://dx.doi.org/10.1007/978-1-4614-0613-6> ;
    schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1244842> ;
    schema:url <http://proxy.library.carleton.ca/login?url=http://books.scholarsportal.info/viewdoc.html?id=/ebooks/ebooks2/springer/2012-05-29/2/9781461406136> ;
    schema:url <http://link.springer.com/openurl?genre=book&isbn=978-1-4614-0612-9> ;
    schema:url <https://link.springer.com/openurl?genre=book&isbn=978-1-4614-0612-9> ;
    schema:workExample <http://worldcat.org/isbn/9781461406136> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/757821413> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/1009148976#Series/cancer_drug_discovery_and_development> # Cancer drug discovery and development.
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/757821413> ; # Natural killer T cells : balancing the regulation of tumor immunity
    schema:name "Cancer drug discovery and development." ;
    schema:name "Cancer drug discovery and development" ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Thing/cancer_research> # Cancer Research
    a schema:Thing ;
    schema:name "Cancer Research" ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Thing/pharmacology_toxicology> # Pharmacology/Toxicology
    a schema:Thing ;
    schema:name "Pharmacology/Toxicology" ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/cytotoxicity_immunologic> # Cytotoxicity, Immunologic
    a schema:Intangible ;
    schema:name "Cytotoxicity, Immunologic"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/health_&_fitness_diseases_general> # HEALTH & FITNESS--Diseases--General
    a schema:Intangible ;
    schema:name "HEALTH & FITNESS--Diseases--General"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_clinical_medicine> # MEDICAL--Clinical Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Clinical Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_diseases> # MEDICAL--Diseases
    a schema:Intangible ;
    schema:name "MEDICAL--Diseases"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_evidence_based_medicine> # MEDICAL--Evidence-Based Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Evidence-Based Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/medical_internal_medicine> # MEDICAL--Internal Medicine
    a schema:Intangible ;
    schema:name "MEDICAL--Internal Medicine"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/natural_killer_t_cells_immunology> # Natural Killer T-Cells--immunology
    a schema:Intangible ;
    schema:name "Natural Killer T-Cells--immunology"@en ;
    .

<http://experiment.worldcat.org/entity/work/data/1009148976#Topic/tumors_immunological_aspects> # Tumors--Immunological aspects
    a schema:Intangible ;
    schema:name "Tumors--Immunological aspects"@en ;
    .

<http://id.loc.gov/authorities/subjects/sh85138558> # Tumors--Immunological aspects
    a schema:Intangible ;
    schema:name "Tumors--Immunological aspects"@en ;
    .

<http://viaf.org/viaf/223140488> # Masaki Terabe
    a schema:Person ;
    schema:familyName "Terabe" ;
    schema:givenName "Masaki" ;
    schema:name "Masaki Terabe" ;
    .

<http://viaf.org/viaf/75301850> # Jay A. Berzofsky
    a schema:Person ;
    schema:familyName "Berzofsky" ;
    schema:givenName "Jay A." ;
    schema:name "Jay A. Berzofsky" ;
    .

<http://worldcat.org/entity/work/data/1009148976#CreativeWork/natural_killer_t_cells>
    a schema:CreativeWork ;
    rdfs:label "Natural killer T cells." ;
    schema:description "Print version:" ;
    schema:isSimilarTo <http://www.worldcat.org/oclc/757821413> ; # Natural killer T cells : balancing the regulation of tumor immunity
    .

<http://worldcat.org/isbn/9781461406136>
    a schema:ProductModel ;
    schema:isbn "1461406137" ;
    schema:isbn "9781461406136" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.