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Neoplastic transformation in human cell culture : mechanisms of carcinogenesis

Author: Johng S Rhim; Anatoly Dritschilo; Georgetown University. Department of Radiation Medicine.; University of Chicago. Department of Radiation and Cellular Oncology.
Publisher: Totowa, N.J. : Humana Press, ©1991.
Series: Experimental biology and medicine (Clifton, N.J.)
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Summary:
"Rhim and Dritschilo's state-of-the-art volume on Neoplastic Transformation in Human Cell Culture highlights the latest findings on the role of carcinogenic agents in the development of human cancers using a variety of human cells as experimental model systems. Chapters cover all the latest results on the transformation of human cells in culture and provide new insight into the molecular and cellular changes that  Read more...
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Genre/Form: Congresses
Conference proceedings
Conference papers and proceedings
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: Johng S Rhim; Anatoly Dritschilo; Georgetown University. Department of Radiation Medicine.; University of Chicago. Department of Radiation and Cellular Oncology.
ISBN: 0896032272 9780896032279
OCLC Number: 24504412
Notes: Papers from a workshop held at Georgetown University Medical Center, Washington, DC, on April 25-26, 1991, sponsored by the Georgetown University Dept. of Radiation Medicine and the University of Chicago, Dept. of Radiation and Cellular Oncology.
Description: xxxi, 396 pages : illustrations ; 24 cm.
Contents: I. Preneoplastic Events.- Comparison of human versus rodent cell transformation: importance of cell aging.- Deficient DNA repair, an early step in neoplastic transformation of human cells in culture.- Use of immortalized human keratinocytes for the study of squamous differentiation and mutagenesis.- Studies of mutagen-activated genes which confer anchorage-independence: the c-sis gene as a model.- Cytoskeletal changes in human transformed cells: Studies on HOS cells.- Polyamine metabolism in human epidermal keratinocytes transformed with AD12-SV40, HPV16-DNA, and K-ras oncogene.- II. Radiation Transformation and Oncogenes.- Transformation of human diploid fibroblasts by radiation and oncogenes.- Ionizing radiation-mediated protein kinase C activation and gene expression.- Detection of transforming genes from radiation transformed human epidermal keratinocytes by a tumorigenicity assay.- Neoplastic transformation of human epithelial cells by ionizing radiation.- Effects of ionizing radiation on human papillomavirus immortalized human bronchial epithelial cells.- Biochemical purification of a CSF-1 like molecule released during malignant transformation of IL-3 dependent hematopoietic progenitor cell lines cocultivated with gamma irradiated clonal marrow stromal cell lines.- An inherited p53 point mutation in a cancer prone family with Li-Fraumeni syndrome.- p53, a direct target of mutational activation by chemical carcinogens?.- III. Viral Transformation and Oncogenes.- The HIV tat gene induces epidermal hyperplasia in vivo and transforms keratinocytes in vitro.- Immortalization and tumorigenic transformation of normal human cervical epithelial cells transfected with human papillomavirus DNAs.- Using the papillomavirus E6/E7 genes to generate well-differentiated epithelial cell lines.- Tumor progression in breast cancer.- Growth regulation of HPV-positive keratinocytes by TGF-01.- Cell growth transformation by Epstein Barr virus.- Isolation and characterization of a transformation-associated gene from human nasopharyngeal carcinoma cells.- Molecular pathogenesis of lung cancer: Mutations in dominant and recessive oncogenes and the expression of opioid and nicotine receptors in the pathogenesis of lung cancer.- Molecular control of expression of plasticity of tumorigenic/ metastatic phenotypes.- IV. Multistep Models.- Altered regulation of growth and differentiation at different stages of transformation of human skin keratinocytes.- Neoplastic transformation and suppression of transformation of human bronchial epithelial cells in vitro.- An in vitro human mammary epithelial model system for studies of differentiation and carcinogenesis.- Transformation in vitro of human uroepithelial cells.- Multiple steps in the in vitro immortalization and neoplastic conversion of human colonic epithelial cells.- A human renal epithelial multistep model of in vitro carcino-genesis.- Immortalization and oncogene transformation of human esopha-geal epithelial cells.- A nontumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations.- Establishment and characterization of SV40 T-antigen immortal-ized human liver cells.- Transformation of human tracheal gland epithelial cells in vitro.- Stable expression of SV40 large T-antigen gene in primary human Schwann cells.- Malignant transformation of human fibroblasts in vitro.- Mitogen-independence and autocrine growth factor secretion displayed by human mesothelioma cells and oncogene-transfected mesothelial cells.- Structure and growth regulation in normal, Transformed and malignant human endometrial cell cultures.- Construction of a unidirectional cDNA library from a radio-resistant laryngeal squamous cell carcinoma cell line in an Epstein Barr virus shuttle vector.- Contributors.- Registrants.
Series Title: Experimental biology and medicine (Clifton, N.J.)
Responsibility: edited by Johng S. Rhim, Anatoly Dritschilo.
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Abstract:

The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi- mental model systems.  Read more...

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...should be a part of any departmental library serving virologists, cell biologists, pathologists, and other scientists interested in malignant cell growth.-Quarterly Review of Biology

 
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