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Nephrotoxicity : in vitro to in vivo : animals to man

Author: P H Bach; E A Lock
Publisher: New York : Plenum Press, ©1989.
Edition/Format:   Print book : Conference publication : EnglishView all editions and formats
Database:WorldCat
Summary:

Proceedings held Aug. 1987. Papers cover heavy metal toxicity; aminoglyosides and lithium; platinum anticancer drugs and other therapeutic agents; radiological contrast media; nuclear magnetic  Read more...

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Genre/Form: Congresses
Congrès
Additional Physical Format: Online version:
International Symposium on Nephrotoxicity (3rd : 1987 : University of Surrey).
Nephrotoxicity.
New York : Plenum Press, ©1989
(OCoLC)556150295
Online version:
International Symposium on Nephrotoxicity (3rd : 1987 : University of Surrey).
Nephrotoxicity.
New York : Plenum Press, ©1989
(OCoLC)608910064
Material Type: Conference publication
Document Type: Book
All Authors / Contributors: P H Bach; E A Lock
ISBN: 030643153X 9780306431531
OCLC Number: 19393132
Notes: "Proceeding of the Third International Symposium on Nephrotoxicity: Extrapolation from Animals to Man and In Vitro to In Vivo, held August 3-7, 1987, at the University of Surrey, Guildford, Surrey, United Kingdom"--Title page verso.
Description: xx, 765 pages : illustrations ; 26 cm
Contents: Species differences in renal structure and function - Applications to the assessment of nephrotoxicity in man.- Lead induced nephrotoxicity: kidney calcium as an indicator of tubular injury.- Predicting the kidney burden of toxic metals.- A prospective study of proteinuria in cadmium workers.- Red blood cell negative charges as an index of the glomerular polyanion in chronic cadmium poisoning.- Some considerations on critical concentration of cadmium for renal toxicity in rats.- Historical perspective on cadmium-induced nephrotoxicity.- Cadmium may predispose mice to immune complex-mediated renal injury: another possible mechanism for cadmium-induced nephrotoxicity.- Nephrotoxicity of cadmium in chickens.- Differential effects of cadmium and mercury on lysosomal enzymes in the kidney of Myxine glutinosa.- The effects of cadmium and adriamycin on the isolated perfused glomerulus of Myxine glutinosa (Cyclostomata).- Protective effect of low concentrations of mercury against mercuric chloride-induced nephrotoxicity.- Induction of antinuclear antibodies by mercuric chloride in mice.- Analysis of unscheduled DNA synthesis and S-phase synthesis in F344 rat kidney after in vivo treatment with mercuric chloride.- In vitro and in vivo mercuric chloride-induced nephrotoxicity assessed by tubular enzymes release.- Prevention and reversal of mercuric chloride-induced increases in renal vascular resistance by captopril.- Regioselective acute tubular necrosis in renal cortical slices following mercuric chloride and potassium dichromate: localization and transport studies.- In-vivo bone lead measurements and renal effects.- Early indicators of lead nephropathy.- Nephrotoxicity of uranyl fluoride and reversibility of renal injury in the rat.- Low molecular weight proteins in the kidney of copper-loaded rats.- Gold nephropathy - effect of gold on immune response to renal tubular basement membrane (TBM) antigen in mice.- Drug induced renal effects of cyclosporine, aminoglycoside antibiotics and lithium: extrapolation of animal data to man.- Lithium-induced distal nephron dilatation in young rabbits with associated encephalitazoan cuniculi related interstitial fibrosis.- Urinary phospholipids patterns after treatment with aminoglycoside antibiotics and cis-platinum.- Comparative uptake and lysosomal phospholipidosis induced by gentamicin components C1, C1a and C2.- Uptake and subcellular distribution of poly-L-aspartic acid, a protectant against aminoglycoside-induced nephrotoxicity, in rat kidney cortex.- Aminoglycoside antibiotics inhibit the phophatidylinositol cascade in renal proximal tubular cells : possible role in toxicity.- Silymarin ameliorates gentamicin nephrotoxicity.- Possible role of the renin-angiotensin system in the development of gentamicin nephrotoxicity in the rat.- Effect of furosemide and verapamil on gentamicin nephrotoxicity.- Renal phospholipidosis in rats after gentamicin and pefloxacin coadministration at low doses.- Morphological and functional impairments of the developing rat kidney exposed to gentamicin in utero.- Morphological and functional effects in rat neonates of aminoglycosides given to the mother during gestation.- Gentamicin-stimulated increase in para-aminohippurate uptake in renal cortical slices and isolated proximal tubular cells.- Investigation of gentamicin nephrotoxicity using renal brush border membrane vesicles.- Time dependent nephrotoxicity of amikacin.- Effect of latamoxef [Moxalactam] on tobramycin binding to kidney brush border membranes in rats.- Amphotericin-B nephrotoxicity is decreased by intravenous flucytosine in the rat.- Apparent amoxapine nephrotoxicity: dependence on rhabdomyolysis and acidosis.- Mechanisms of cyclosporin A nephrotoxicity - rat to man.- The effects of cyclosporin A on the urine excretion of specific proteins in humans.- Renal tubular function in experimental and clinical cyclosporin nephrotoxicity.- The effect of biliary cannulation or ligation on cyclosporin A (CsA) nephrotoxicity in the rat.- Cyclosporine A-induced lipid peroxidation in rat renal microsomes and effect on glucose uptake by renal brush border membrane vesicles.- Chronic renal tubular damage caused by cyclosporin A.- Effects of acute and chronic cyclosporine administration on glomerular haemodynamics in rats.- Intracellular localization of cyclosporin A in the rat kidney.- Distribution of platinum amongst the subcellular organelles of the rat kidney after oral administration of cisplatin.- Alpha-methylglucose uptake by isolated rat kidney proximal tubular cells as a parameter for cell integrity in vitro.- Lipid peroxidation as a mechanism of cisplatin-induced nephrotoxicity.- Renal toxicity of cis-dichlorodiammine platinum in rats.- Uptake of cisplatin (195mpt) into LLCPK1 cells in the presence of diethyldithiocarbamate, (DDTC) mercaptoethane-sulphate (MESNA) and amiloride.- The effect of amiloride on cisplatin induced nephrotoxicity and the renal uptake of cisplatin (195mpt) in male Wistar rats.- The response of the pig kidney to a combination of cisplatin and irradiation.- The effect of acetazolamide and furosemide on lithium clearance and cisplatin nephrotoxicity in the rat.- Sensitivity of in vitro ion accumulation, gluconeogenesis and other parameters as indicators of cisplatin-induced renal toxicity.- Assessment of nephrotoxicity by analysis of a randomised multi-centre comparative study regarding the previous extent of kidney damage.- Drug pharmacokinetics in renal failure - influence of disease type.- Analgesic related renal injury in man.- Progression of renal failure in analgesic associated nephropathy.- The renal reponse of a nonhuman primate (baboon) to certain nonsteroidal anti-inflammatory drugs.- Morphological changes in the pig kidney associated with an acutely induced renal papillary necrosis.- Upper urothelial carcinoma, using N-butyl-N-(4-hydroxybutyl)-nitrosamine and an acute papillary necrosis.- High resolution microscopic changes in an acutely induced renal papillary necrosis: morphology and enzyme histo-chemistry.- Cannulation of the bile duct protects against para-aminophenol-induced nephrotoxicity in the Fischer 344 rat.- Effects of antidotes on the hepato- and nephro-toxicity of paracetamol in the rat.- Celiptium induced lipid peroxidation and toxicity in rat renal cortex.- Nephrotoxicity of ifosfamide in combination chemotherapy.- Risk evaluation of muzolimine and furosemide in experimental models of nephrotoxicity.- The role of oxidative stress in cephaloridine nephrotoxicity.- Studies on the mechanism of radiological contrast media induced renal failure.- Radiocontrast nephrotoxicity in diabetes: clinical considerations and studies in the diabetic rat.- Renal microcirculation during urographic contrast media administration.- Hypertonic radiocontrast medium and the kidney: effects on renal function in the euvalaemic and in the dehydrated dogs.- Renal effects of ionic and nonionic contrast media: comparison between diatrizoate meglumine and Iopamidol.- Renal proton nuclear magnetic resonance in gentamicin, cyclosporin A and cisplatinum, acute renal failure in rats.- 31Phosphorus NMR studies of mercuric chloride nephrotoxicity in the in vitro perfused rat kidney.- Application of 1H NMR urinalysis to the examination of nephrotoxic lesions induced by mercuric chloride, hexachloro-1, 3-butadiene, and propyleneimine.- Pathogenesis of protein droplet nephropathy and its relationship to renal carcinogenesis in the male rat.- Light hydrocarbon-induced nephrotoxicity: the interaction of 2,2,4-trimethylpentane with alpha-2u-globulin in the male rat kidney.- Male rat specific alpha-2u-globulin nephropathy and renal tumorigenesis.- Nephrotoxicity and studies on the reabsorption and disposal of alpha-2u-globulin.- Induction of hyaline droplet accumulation in renal cortex of male rats by aromatic compounds.- 1,4-Dichlorobenzene-induced nephrotoxicity: similarity with unleaded gasoline-induced renal effects.- Comparison of the subacute nephrotoxicity of industrial solvents in the rat.- Nephrotoxic responses to multiple chemical exposure.- Dichlorovinyl cysteine accumulation and ?-lyase activity in the developing mouse kidney.- Regioselective toxicity by dichlorovinylcysteine in rabbit renal cortical slices.- Use of LLC-PK1 monolayers as an in vitro model for nephrotoxicity.- Bioactivation, mechanism and cytotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.- Role of biotransformation in acute N-(3,5-dichlorophenyl)-succinimide-induced nephrotoxicity.- Chloroform nephrotoxicity and renal uptake of calcium.- Renal pathology of orally administered L-triiodothyronine in the rat.- Lipid peroxidation as a possible cause of ochratoxin A toxicity.- Silicon in uremic rats.- Nephrotoxicity of experimental endotoxaemia in rats.- Studies on a physiologic model for the human renal Fanconi syndrome.- Chronic ureter cannula in pig.- Effects of glycerol-induced acute renal failure on renal phosphorus handling.- Renal haemodynamics and renin response during acute hypercapnea in dogs.- The isolated perfused rat kidney: filtering and non-filtering models in the assessment of altered renal vascular resistance in nephrotoxicity.- Endotoxin-hemoglobin induced nephropathy and haptoglobin administration.- Partially purified bovine atrial fraction on animal kidney, smooth muscle and sodium transport in toad skin.- Investigations on the nephrotoxic potential of recombinant human tumor necrosis factor.- Characterisation of human renal embryonic antigens by monoclonal antibodies.- Species differences in the immunocytochemical distribution of Tamm-Horsfall glycoprotein.- Immunocytochemical localization of glutathione peroxidase in uremic rat kidney.- Urine glutathione-S-transferase associated with nephrotoxic drugs.- Age-related changes in renal brush borders brush border enzymes.- Characterization of isolated renal proximal tubules for nephrotoxicity studies.- Isolated rat renal proximal tubular cells: a model to investigate drug-induced nephrotoxicity.- Ion deregulation in injured proximal tubule epithelial cells.- Lipophilic cations as membrane probes in cultured renal (LLC-PK1) and muscle cells (L6).- Characterization of an unscheduled DNA synthesis assay with a cultured line of porcine kidney cells (LLC-PK1).- Micropuncture studies on mechanisms of proteinuria in early adriamycin-nephrosis in MWF-rats.
Responsibility: edited by P.H. Bach and E.A. Lock.

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