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The network collective : rise and fall of a scientific paradigm

Author: Klaus Eichmann
Publisher: Basel ; Boston : Birkhäuser, ©2008.
Edition/Format:   eBook : Document : EnglishView all editions and formats
The network paradigm dominated immunological research from the early 1970s to the late 1980s. The originator, Niels Jerne, hypothesized that the vast diversity of antibodies in each individual forms a network of mutual "idiotypic" recognition, thus regulating the immune system. In context of emerging concepts of systems biology such as cybernetics and autopoesis, the "Eigenbehavior" of the immune system fascinated  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Eichmann, Klaus, 1939-
Network collective.
Basel ; Boston : Birkhäuser, ©2008
(DLC) 2008930062
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Klaus Eichmann
ISBN: 9783764383725 3764383720 9783764383732 3764383739
OCLC Number: 406518778
Description: 1 online resource (vi, 274 pages) : illustrations
Contents: Autobiographical note --
Autobiographical note --
Scientific Knowledge, Delusive or Deductive --
Realism, constructivism, and the naiveté of the experimental scientist --
Beyond underdeterminism: Popper, Kuhn, et al. --
The anthropology of science: Ludwik Fleck et al. --
The science wars --
Origins, Rise, and Fall of the Network Paradigm --
The immune system, pre-network paradigms --
The necessity for an interactive theory of immunity --
Proto-ideas of the network theory: antibody self-regulation, idiotypy, the brain analogy, and cybernetics --
The idiotypic network theory --
The T cell receptor puzzle --
Suppression turned idiotypic --
Network mannerism --
Post-network immunology: Idiotypic network continues at the bedside --
Hindsight --
Science between Fact and Fiction --
The fictional nature of scientific notions --
Fiction turned fact: The case of antibodies --
The enticing network: Fiction forever --
Logic and laws in life science.
Responsibility: Klaus Eichmann.


The network paradigm once dominated immunological research and even garnered its originator a Nobel Prize. It has since been criticized and largely abandoned. This book is a firsthand account of the  Read more...
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