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Neurodegeneration : metallostasis and proteostasis

Author: Danilo Milardi; E Rizzarelli
Publisher: [Cambridge] : Royal Society of Chemistry, ©2011.
Series: RSC drug discovery series.
Edition/Format:   Print book : EnglishView all editions and formats
This book covers the latest developments in the understanding the pathogenesis of neurodegenerative diseases.

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Document Type: Book
All Authors / Contributors: Danilo Milardi; E Rizzarelli
ISBN: 9781849730501 1849730504
OCLC Number: 756212712
Description: xiv, 270 pages : illustrations (some color) ; 24 cm.
Contents: Chemical evolution, brain and metallomics; Chemistry and biology of proteostasis; Environmental factors affecting cellular proteostasis; Neurodegeneration and cell membranes; The role of Metals in the intracellular clearance of amyloids; Speciation, coordination sites and metal binding affinities of proteins related to neurodegeneration; Copper, Zinc and trophic factors in neurodegeneration; Metals as catalysts of ROS production in neurodegeneration; Metal hypothesis of Alzheimer disease; Copper supply and metal homeostasis in AD; The role of iron in neurodegeneration; Aluminium in neurodegenerative diseases; Zinc trafficking in the AD brain; The role of metal ions in the pathogenesis of Parkinson's disease; Metals in ALS pathology; Metals and prion diseases
Series Title: RSC drug discovery series.
Responsibility: Danilo Milardi and Enrico Rizzarelli (editors).


This exemplary book gives an up-to-date perspective on the role of metal ions in neurodegeneration.  Read more...


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The RSC Drug Discovery series presents a good insight into many aspects of drug discovery. In my new role transitioning from a long career in the pharmaceutical industry to academia, the RSC Drug Read more...

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