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Neurotrophic factors

Author: Sandra E Loughlin; James H Fallon
Publisher: San Diego : Academic Press, ©1993.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This volume clearly synthesizes current information on defined neurotrophic factors, emphasizing their localization and molecular/cellular function in the central nervous system. Brain development and aging, neurodegenerative disorders, plasticity, and memory all are closely examined within the context of this rapidly expanding field. Researchers in neurobiology, cell biology, and molecular biology will find  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(DLC) 92011683
(OCoLC)25630303
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Sandra E Loughlin; James H Fallon
ISBN: 9780080571324 0080571328
OCLC Number: 638736333
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xxi, 607 pages) : illustrations (some color)
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Cover image; Title page; Table of Contents; Copyright page; Contributors; Preface; 1: Functional Implications of the Anatomical Localization of Neurotrophic Factors; I INTRODUCTION; II NEUROTROPHIC FACTORS INCLUDED IN THIS VOLUME; III REVIEW OF CELLULAR EVENTS OF NEUROTROPHIC FACTOR SYSTEMS; IV MODES OF SECRETION AND TRANSPORT OF NEUROTROPHIC FACTORS; V NEUROTROPHIC FACTOR DISTRIBUTION IN CENTRAL NEURAL SYSTEMS; VI SUMMARY; ACKNOWLEDGMENTS; 2: Neurotrophic Factors: What Are They and What Are They Doing?; I HISTORY; II DEFINITION; III PHYSIOLOGICAL FUNCTIONS OF NEUROTROPHIC FACTORS. IV PHARMACOLOGICAL EXPLOITATION OF NEUROTROPHIC FACTORSV CONCLUSIONS; 3: Synergy, Retrograde Transport, and Cell Death; I INTRODUCTION; II CELL DEATH; III AXOPLASMIC TRANSPORT; IV INTERACTIONS BETWEEN NEURONALLY ACTIVE MOLECULES; V MECHANISMS OF INTERACTION; VI OTHER MECHANISMS TO ACHIEVE A RETROGRADE MESSAGE; VII CONCLUSIONS; 4: Primary Response Gene Expression in the Nervous System; I INTRODUCTION; II fos AND jun GENES AS PROTOTYPICAL PRIMARY RESPONSE GENES; III OTHER PRIMARY RESPONSE GENES; IV IN VITRO EXPRESSION OF PRIMARY RESPONSE GENES IN NEURAL SYSTEMS. V IN VIVO EXPRESSION OF PRIMARY RESPONSE GENESVI SECONDARY RESPONSE GENES AS TARGETS OF PRIMARY RESPONSE GENES; VII SPECIFICITY OF PRIMARY RESPONSE GENE EXPRESSION; 5: Nerve Growth Factor and Related Substances: Structure and Mechanism of Action; I INTRODUCTION; II NGF STRUCTURE; III RECEPTORS; IV MECHANISM OF ACTION OF NGF; V SUMMARY AND CONCLUSIONS; ACKNOWLEDGMENTS; 6: Regulation of Nerve Growth Factor Expression; I EXPRESSION IN THE TARGET; II EXPRESSION IN NEURAL SUPPORTING CELLS AFTER INJURY; III EXPRESSION IN EARLY DEVELOPMENT AND NONNEURAL SETTINGS. IV BIOLOGIC SIGNIFICANCE OF NGF REGULATION:STRATEGIES FOR MANIPULATION IN VIVO7: Nerve Growth Factor: Actions in the Peripheral and Central Nervous Systems; I INTRODUCTION; II NGF ACTIONS IN THE PERIPHERAL NERVOUS SYSTEM; III NGF ROLE IN THE CENTRAL NERVOUS SYSTEM; 8: Brain-Derived Neurotrophic Factor: An NGF-Related Neurotrophin; I INTRODUCTION; II NGF: PROTOTYPICAL NEUROTROPHIC FACTOR; III SEARCH FOR OTHER NEUROTROPHIC FACTORS; VI DISCOVERY OF NEUROTROPHIC "ACTIVITIES" DISTINCT FROM NGF; V PURIFICATION OF BDNF FROM PORCINE BRAIN; VI NEURONAL SPECIFICITY OF BDNF. VII BDNF PREVENTS NEURONAL DEATH IN VIVOVIII MOLECULAR CLONING OF PORCINE, MOUSE, RAT, AND HUMAN BDNF; IX CONSEQUENCES OF THE MOLECULAR CLONING OF BDNF; X BINDING OF BDNF TO SPECIFIC RECEPTORS; XI NEUROTROPHIN FAMILY OF NGF-RELATED NEUROTROPHIC FACTORS-NGF, BDNF, NT-3, AND OTHERS; XII CLINICAL PERSPECTIVE; XIII CONCLUSIONS; ACKNOWLEDGMENTS; 9: Biochemistry and Molecular Biology of Fibroblast Growth Factors; I INTRODUCTION; II STRUCTURE AND EXPRESSION OF FGF GENES; III PROTEIN STRUCTURES; IV RECEPTORS; V INHIBITORS; VI SIGNAL TRANSDUCTION; VII BIOLOGIC FUNCTIONS.
Responsibility: edited by Sandra E. Loughlin and James H. Fallon.
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Abstract:

Synthesizes information on defined neurotrophic factors, emphasizing their localization and molecular/cellular function in the central nervous system. This book also examines brain development and  Read more...

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