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The neutrophil : an emerging regulator of inflammatory and immune response ; the most recent findings on the functional roles of neutrophils

Author: Marco A Cassatella
Publisher: Basel Karger 2003
Series: Chemical immunology and allergy, 83
Edition/Format:   Computer file : EnglishView all editions and formats
Summary:
In the past, neutrophils were often reduced to their ability to release preformed mediators and kill pathogens. The present volume of Chemical Immunology and Allergy, however, offers a very broad and timely view by highlighting the versatile functions of neutrophils in inflammatory, immune and antitumoral responses.Leading investigators uncover novel aspects of neutrophils, such as their capacity to control gene  Read more...
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Details

Material Type: Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Marco A Cassatella
OCLC Number: 837708916
Description: Online-Ressource.
Series Title: Chemical immunology and allergy, 83
Responsibility: vol. ed.: Marco A. Cassatella

Abstract:

In the past, neutrophils were often reduced to their ability to release preformed mediators and kill pathogens. The present volume of Chemical Immunology and Allergy, however, offers a very broad and timely view by highlighting the versatile functions of neutrophils in inflammatory, immune and antitumoral responses.Leading investigators uncover novel aspects of neutrophils, such as their capacity to control gene expression at the transcriptional level, or respond to proinflammatory cytokines, cytokine receptor chains (gc) and endogenous anti-inflammatory lipid mediators. Further points under discussion are neutrophils presenting antigens, activating T cells, participating in chemokine networking, and producing IL-12 and other cytokines during infectious diseases. Among the most original findings presented in this publication figure the observations that neutrophils cause increased vascular permeability during acute inflammation, regulate directly the angiogenic process, and influence tumor development. A final article offers a detailed description of the molecular processes affecting neutrophil cell death and survival.Unique in its field, this valuable volume is recommended reading not only for immunologists and pathologists, but also for cell biologists, hematologists and immunobiologists

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