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Next Generation Sequencing in Cancer Research : Volume 1: Decoding the Cancer Genome.

Author: Wei Wu; Hani Choudhry
Publisher: Dordrecht : Springer, 2013.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology. This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Wu, Wei.
Next Generation Sequencing in Cancer Research : Volume 1: Decoding the Cancer Genome.
Dordrecht : Springer, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wei Wu; Hani Choudhry
ISBN: 9781461476450 1461476453
OCLC Number: 858763604
Notes: 4.2 11q13.3 Allele-Specific Effects on HIF-Binding, Epigenetic Environment and CCND1 Expression.
Description: 1 online resource (383 pages)
Contents: Preface; Contents; Contributors; Chapter 1: The Evolution of High-Throughput Sequencing Technologies: From Sanger to Single-Molecule Sequencing; 1 Introduction; 2 From Sanger Sequencing to NGS Technologies; 2.1 Sanger Sequencing; 2.2 Next-Generation Sequencing Technologies (Massive Parallel Sequencing); 2.2.1 Sequencing Throughput; 2.2.2 Sequencing Chemistry and Approach; 2.2.3 Sequence Read Length and Error Rate; 2.3 Bench-Top NGS Platforms; 3 Single-Molecule Sequencing Technologies; 3.1 Helicos BioSciences: True Single-Molecule Sequencing (tSMS). 3.2 Pacific Biosciences: Single-Molecule Real-Time (SMRT) Sequencing4 Other Sequencing Technologies; 5 Summary; References; Chapter 2: Next-Generation Sequencing in Cancer Epigenomics and Potential Clinical Applications; 1 Introduction; 2 Advances in the Study of Epigenomics; 2.1 DNA Methylation; 2.2 Histone Modifications; 2.3 microRNAs; 2.4 Other Epigenetic Mechanisms; 3 Conclusions; References; Chapter 3: Next-Generation Sequencing for Cancer Genomics; 1 Introduction; 2 Understanding Cancer Genomics Using the Whole Genome Sequencing Approach. 3 Understanding Cancer Genomics Using the Targeted Resequencing Approach4 Understanding Cancer Genomics Using Transcriptome Profiling Approach; 5 Understanding Cancer Genomics Using Methylation Profiling; 6 Bioinformatic Analysis Approach for Resequencing, Transcriptome Profiling, and Methylation Analysis; 7 Advantages and Disadvantages of NGS Technology; 7.1 Advantages; 7.2 Disadvantages; 8 Summary and Future Directions; References; Chapter 4: Genomic Landscape of Cancer Metastasis; 1 Introduction; 2 Metastasis; 2.1 Events of the Metastasis Cascade; 2.1.1 Local Invasion; 2.1.2 Intravasation. 2.1.3 Survival in the Circulation2.1.4 Extravasation; 2.1.5 Micrometastasis and Macrometastasis; 2.2 Models of Metastasis; 2.2.1 Unidirectional or Multidirectional Metastasis; 2.2.2 Linear and Parallel Model of Metastasis; 3 Genomic Signature of Metastasis Revealed by Next Generation Sequencing (NGS); 4 The Role of ncRNAs in Cancer Metastasis; 4.1 Small Noncoding RNAs (SncRNAs); 4.2 Long Noncoding RNAs (lncRNAs); 4.3 Advancement in Technology for the Discovery of lncRNAs; 5 LncRNAs Associated with Cancer Metastasis; 5.1 MALAT-1; 5.2 HOTAIR; 5.3 BC200; 5.4 SRA RNA; 6 Summary; References.

Abstract:

This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology. This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for.

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