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Nitrates III : Cardiovascular Effects

Author: P R Lichtlen; H -J Engel; A Schrey; H J C Swan
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1981.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:

Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. Although most investigators agree that intracellular sequestration of calcium is probably the  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Printed edition
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: P R Lichtlen; H -J Engel; A Schrey; H J C Swan
ISBN: 9783642680878 3642680879 9783642680854 3642680852
OCLC Number: 851836606
Description: 1 online resource (volumes)
Contents: I Basic Action of Nitrates.- Pharmacology of Nitrates in Relation to Antianginal Action.- Pharmacokinetics - Pharmacodynamics and the Bioavailability of Organic Nitrate Drug Products.- Fate of Isosorbide Mononitrates in Man.- Tolerance to Circulatory and Clinical Effects of Nitrates.- Panel Discussion.- II Pharmacodynamics and Kinetics.- Pharmacokinetics of Isosorbide Dinitrate in Human Subjects.- Pharmacokinetics of Isosorbide Mononitrates in Human Subjects.- Comparative Haemodynamic and Pharmacokinetic Investigations After Oral Isosorbide-2-mononitrate and Isosorbide-5-mononitrate.- Newer Methods of Administration of Nitrates to Man to Give a More Predictable Therapeutic Response.- Plasma Concentrations and Hemodynamic Effects of Percutaneously Administered Nitroglycerin and Isosorbide Dinitrate in Healthy Volunteers.- Effects of Acute and Chronic Administration of Isosorbide Dinitrate, Sustained-Release Form, in Patients with Angina Pectoris.- May Prolonged High Doses of Nitrates Cause Tolerance? Preliminary Results on the Response to an Additional Dose by Infusion.- The New Tropical Drug Delivery System for Nitroglycerin.- Echocardiographic Assessment of Different Doses of Oral Isosorbide Dinitrate in Patients with and without Heart Failure: Increase in Response with Dose.- Unchanged Efficacy of Acute Sublingual Nitrate Compounds During Long-term Treatment with Percutaneously Applied Isosorbide Dinitrate Ointment.- Induction and Inhibition of Organic Nitrate Metabolism.- Digital Pulse Plethysmography: a Sensitive Test of the Pharmacodynamics of Nitrates - Reproducibility and Quantitation of the Technique.- Discussion.- III Hemodynamics.- Direct and Indirect Effects of Nitroglycerin on Systolic and Diastolic Left Ventricular Function.- Left Ventricular Function and Regional Wall Motion After Intracoronary Application of Nitrates in Coronary Heart Disease..- Different Effects of Intracoronary and Intravenous Administration of Nitroglycerin on the Microcirculation of the Ventricular Myocardium of the Cat and Rat Heart.- Diastolic Pressure-Volume Relation and Left Ventricular Mass in Man After Autonomic Blockade and During Afterload Variation with Isosorbide Dinitrate and Methoxamine.- Early Hemodynamic Responses to Single Dose Intravenous Nitroglycerin: Time Course Relationships.- Demonstration of a Real Inotropic Effect of Nitrites on Myocardial Contractility During Anoxia and Reoxygenation: Attempt to Determine Action Site with the Contribution of Calcium Antagonistic Compounds.- Use of Intravenously Administered Isosorbide Dinitrate to Determine Reversibility of Myocardial Asynergy After Myocardial Infarction.- Hemodynamic Interaction of Beta-Blockers and Nitrates in Coronary Heart Disease.- Discussion.- IV Coronary Flow, Perfusion.- Effect of Nitrates on Myocardial Blood Flow During Angina: Comparison of Results Obtained by Inert Gas Clearance and 201 Thallium Imaging.- Collateral Pressure Distal to Coronary Obstructions - Influence of Nitrates.- Effects of Systemic Nitroglycerin on Perfusion of Ischemic Myocardium in Clinical Coronary Artery Disease.- Effects of Nitroglycerin on Blood Velocity and Flow in Coronary Arteries and Bypass Grafts in Man.- The Effect of Nitrates on Pressuretime Indices and Coronary Graft Blood Flow in Man.- Angina Pectoris and Other Effects After Intracoronary Administration of Nitroglycerin.- Discussion.- V Vascular Effects.- Comparative Vasodilating Effects of Nitroglycerin and Verapamil on Large Coronary Arteries in Man.- Quantitative Coronary Angiography: Effect of Isosorbide Dinitrate on Coronary Artery Stenoses.- Threshold Dosages of Nitroglycerin for Coronary Artery Dilatation, Afterload Reduction, and Venous Pooling in Conscious Dogs.- Influence of Nitroglycerin on Aortic Compliance, Capacity of the Windkessel, and Peripheral Resistance.- Echocardiographic Findings of Left Ventricular Function Before and After Isosorbide Dinitrate in Chronic Hemodialysis Patients.- Hemorrheological and Hemodynamic Effects of ISDN in Essential Hypertension and Obliterative Arterial Disease.- Coronary Artery Spasm Combined with Walk-through Phenomenon - a Special Type of Prinzmetal's Angina.- Discussion.- VI Pulmonary Circulation.- Effect of Nitroglycerin on the Diameter of Peripheral Arterial and Venous Pulmonary Vessels.- Nitrates in Patients with Pulmonary Hypertension Due to Airways Obstruction.- Comparison of the Effects of Nitroglycerin and Aminophylline on Hemodynamics and Lung Function in Patients with Chronic Obstructive Lung Disease.- Influence of Nitroglycerin on Central Hemodynamics and $${\dot V_A}/{\dot Q_C}$$ of the Lungs in the Postoperative Period After Coronary Bypass Surgery.- Effect of Sustained-Release Isosorbide Dinitrate on Pulmonary Arterial Hypertension in Patients with Chronic Cor Pulmonale.- Influence of Isosorbide Dinitrate of Pulmonary Circulation and Gas Exchange in Acute Respiratory Distress Syndrome.- Discussion.- VII Acute Myocardial Infarction and Unstable Angina.- The Use of Sodium Nitroprusside in the Treatment of the Acute Phase of Myocardial Infarction.- The Role of Nitroglycerin in Acute Myocardial Infarction.- Nitroprusside and Nitroglycerin in Acute Myocardial Infarction.- The Effect of Intracoronary Nitroglycerin in Acute Myocardial Infarction.- Panel-Discussion.- Intracoronary Thrombolysis in Evolving Myocardial Infarction.- Feasibility of Nitroprusside Therapy in Patients with Hypotension Due to Severe Left Ventricular Failure in Acute Myocardial Infarction.- Vasodilator-Induced Changes in Global and Regional Ventricular Function in Acute Myocardial Infarction.- A Randomized Trial of Prolonged Nitroglycerin Infusion in Acute Myocardial Infarction.- Intravenous Nitroglycerin in Unstable Angina.- The Action of Nitroglycerin on Pacing-Induced Arrhythmias.- Discussion.- VIII Exercise.- Assessment of the Effect of Isosorbide Dinitrate on Left Ventricular Hemodynamics at Rest and Under Exercise in Patients with CHD by Gated Blood Pool Scintigraphy.- Influence of Isosorbide Dinitrate and Mononitrate on the Ejection Fraction and Wall Motion Parameters at Rest and Under Exercise in Patients with Coronary Heart Disease.- Influence of Nitroglycerine on Myocardial Metabolism of Cyclic AMP, Cyclic GMP, Lactate, Free Fatty Acids, and Glucose at Rest and During Exercise in Patients with Coronary Heart Disease.- Attenuation of Nitrate Preload Reduction by Exercise in Patients with Severe Chronic Heart Failure.- Sustained Effect of Isosorbide Dinitrate Ointment on Angina and Exercise-Induced Electrocardiographic Changes in Patients with Ischemic Heart Disease.- Exercise-Induced Nonischemic Angina Pectoris Due to Abnormal Left Ventricular Compliance: Effects of Nitroglycerin.- Long-Term Effects of Isosorbide Dinitrate and Molsidomine on Left Ventricular Wall Motion and Dimensions in Patients with Coronary Heart Disease and Stable Angina Pectoris.- Myocardial Oxygen Consumption and Coronary Blood Flow at Rest and During Exercise After Application of Nitroglycerin.- Effect of Isosorbide Dinitrate and Coronary Bypass Surgery on the Perfusion Distribution and Regional Tracer Uptake in 201 Thallium Stress Scintigraphy.- Effects of Nitrates at Rest and During Bicycle Exercise and Cross-Country Walking.- Discussion.- IX Chronic Heart Failure.- Peripheral Circulation in Congestive Heart Failure.- General Principles of Treatment with Vasodilators.- Chronic Refractory Pump Failure: Effects on Hemodynamics and Circulating Catecholamines of Intravenous Isosorbide Dinitrate.- Treatment of Low-Output Failure After Open Heart Surgery with Nitroglycerin and Dobutamine.- Afterload Reduction with Dipyridamole and Preload Reduction with ISDN in Congestive Heart Failure.- Panel-Discussion.- Effect of Nitroglycerin on Hemodynamics and Catecholamines in Patients with Left Heart Failure.- Dose Response Study of Acute Hemodynamic Effects of Intravenous Isosorbide Dinitrate in Patients with and without Heart Failure.- Comparative Efficacy of Nitroprusside and Prazosin on Cardiocirculatory Function in Chronic Congestive Heart Failure.- Efficacy of Long-Term Nitrate Treatment in Chronic Left Ventricular Failure.- Haemodynamic Effects of High Dose Isosorbide Dinitrate (160mg Daily) in Severe Congestive Heart Failure.- Renal Changes in Low Cardiac Output Failure: Improvement with Vasodilators.- Discussion.- X Bypass Surgery; Valvular Heart Disease.- Comparison of Intravenous Nitroglycerin and Nitroprusside as Arterial Vasodilators.- Influence of Sodium Nitroprusside on Myocardial Function Early After Aortocoronary Bypass Surgery.- Influence of Deliberate Hypotension on Oxygenation and Plasma Catecholamines During Coronary Bypass Surgery.- The Effects of Nitroglycerin in Patients with Valvular Heart Disease: Hemodynamic and Radionuclide Cineangiographic Studies.- Effects of Volume Expansion and Vasodilators on Hemodynamics and Organ Perfusion in Acute Pericardial Tamponade.- Effects of Nitroglycerin on Left Ventricular and Myocardial Function in Aortic Stenosis.- Discussion.- XI Poster Session.- Sodium Nitroprusside: Indication that Peripheral Vascular Beds are the Sites for its Rapid in Vivo Inactivation.- Influence of ISDN, Molsidomine, Nifedipine, and DHE, on the Venous Tone in Man.- Effects of Sodium Nitroprusside (Nipruss) in Addition to Volume Administration in Shock States Associated with Increased Total Peripheral Vascular Resistance.- Organic Nitrates - A New Principle in Glaucoma Therapy?.- Nitrates: Concluding Remarks.
Responsibility: edited by P.R. Lichtlen, H.-J. Engel, A. Schrey, H.J.C. Swan.

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