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Nitric oxide : biology and pathobiology

Author: Louis J Ignarro
Publisher: London : Academic, 2010.
Edition/Format:   eBook : Document : English : 2nd edView all editions and formats
Summary:
Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Nitric oxide.
London : Academic, 2010
(OCoLC)435734695
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Louis J Ignarro
ISBN: 9780123738660 0123738660
OCLC Number: 610009660
Description: 1 online resource
Contents: Section I. Chemical Biology --
Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes --
Nitric oxide redox biochemistry in lipid environments --
Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration --
Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes --
Section II. Principles of Biology --
A. Nitric Oxide Synthases --
Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal --
Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases --
Regulation of the expression of inducible nitric oxide synthase --
Molecular Regulation of Inducible Nitric Oxide Synthase --
B. Guanylate Cyclase and Cyclic GMP --Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation --
C. Nitric Oxide Signaling --
Untargeted Discovery of NO-modified Proteins --
Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids --
Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 --
The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide --
D. Regulation of Nitric Oxide Production --
Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence --
E. Nitric Oxide and Remodeling --
The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies --
F. Nitrite and Nitrate --
NO formation from inorganic nitrate and nitrite --
Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential --
Nitrite Therapy for Ischemic Syndromes --
Nitrite and heme globins: Reaction mechanisms and physiological targets --
Section III. Principles of Pathobiology --
A. Nitric Oxide and Cardiovascular Function --
Nitric Oxide in Vascular Damage and Regeneration --
Free radicals as atherosclerotic risk-The relation of NO- --
The role of oxidative stress in endothelial dysfunction and vascular inflammation --
B. Pathophysiological Mechanisms of Nitric Oxide --
Nitric oxide, oxidative stress, immune response and critical care --
Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury --
Nitric oxide in airway inflammation --
Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance.
Responsibility: edited by Louis J. Ignarro.

Abstract:

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. This title features therapeutic implications of nitric oxide research. It is authored by world experts  Read more...

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