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Nitric oxide (NO) and cancer : prognosis, prevention, and therapy

Author: Benjamin Bonavida
Publisher: New York, NY : Springer, ©2010.
Series: Cancer drug discovery and development.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Nitric oxide (NO) and cancer.
New York, NY : Springer, ©2010
(OCoLC)435733090
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Benjamin Bonavida
ISBN: 9781441914323 1441914323
OCLC Number: 654387798
Language Note: English.
Description: 1 online resource (xx, 513 pages) : illustrations.
Contents: Nitric oxide and cancer: an overview --
A role for eNOS in oncogenic Ras-driven cancer --
Dual role of nitric oxide in cancer biology --
Nitric oxide expression in cancer --
S-nitrosylation: how cancer cells say NO to cell death --
Cytotoxic and protective activity of nitric oxide in cancers --
Cytotoxic/protective activity of nitric oxide in cancer --
Nitric oxide and life or death of human leukemia cells --
Inhibition of apoptosis by endogenous nitic oxide in chronic lymphocytic leukaemia --
Nitric oxide: a rate-limiting factor for metastases development --
Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB/Snail/RKIP loop --
Sensitizing effect of nitric oxide to cytotoxic stimuli --
Nitric oxide is a promising enhancer for cancer therapy --
Role of nitric oxide for modulation of cancer therapy resistance --
Breaking resistance: role of nitric oxide in the sensitization of cancer cells to chemo- and immunotherapy --
Prognositc significance of iNOS in human melanoma --
Prognostic significance of iNOS in hepatocellular carcinoma --
Prognostic significance of iNOS in esophageal cancer --
Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis --
Nitric oxide-releasing molecules for cancer therapy and chemoprevention --
Nitric oxide: monotherapy or sensitiser to conventional cancer treatments? --
Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies --
(S, R)-3-Pheynyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO): new dress for nitric oxide mission --
Nitric oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis --
Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of nitric oxide of HIF-1a: potential role of Se-Methylselenocysteine(MSC), an antioxidant multi-targeted small molecule.
Series Title: Cancer drug discovery and development.
Responsibility: edited by Benjamin Bonavida.

Abstract:

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This mo.

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