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NMR spectroscopy in drug development and analysis

Author: U Holzgrabe; I Wawer; B Diehl
Publisher: Weinheim ; New York ; Chichester : Wiley-VCH, ©1999.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (& 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Holzgrabe, U. (Ulrike).
NMR spectroscopy in drug development and analysis.
Weinheim ; New York ; Chichester : Wiley-VCH, ©1999
(OCoLC)42579355
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: U Holzgrabe; I Wawer; B Diehl
ISBN: 9783527613656 352761365X 9783527613649 3527613641
OCLC Number: 649863884
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (299 pages) : illustrations
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: NMR spectroscopy in the European regulatory dossier / S. Branch --
Analysis of drugs / B.W.K. Diehl and U. Holzgrabe --
pH-dependent NMR measurements / G. Hägele and U. Holzgrabe --
Complexation behaviour of drugs studied by NMR / B.W.K. Diehl and U. Holzgrabe --
Determination of the isometric composition of drugs / B.W.K. Diehl and U. Holzgrabe --
On-line coupling of HPLC or SFC / K. Albert --
NMR of body fluids / U. Holzgrabe --
NMR as a tool in drug research / G. Gemmecker --
Ligand-cyclodextrin complexes / B. Chankvetadze, G. Blaschke and G. Pintore --
Ligand-membrane interaction / J.K. Seydel --
Solid-state NMR in drug analysis / I. Wawer --
MR imaging and MR spectroscopy / I. Wawer.
Responsibility: U. Holzgrabe, I. Wawer, B. Diehl.

Abstract:

Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (& 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition o.

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