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Novel Approaches to the Treatment of Alzheimer's Disease

Author: Edwin M Meyer; James W Simpkins; Jyunji Yamamoto
Publisher: Boston, MA : Springer US, 1990.
Series: Advances in Behavioral Biology, 36; Advances in behavioral biology, 36.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Alzheimer's disease afflicts up to 1 in 5 people over the age of 65 years and causes untold suffering of the patient and their family. The cause of this disease is unknown; indeed, evidence increasingly suggests that there may be multiple Alzheimer-type syndromes with different etiologies, analogous to different types of psychosis. Currently there are no means to prevent the disease, slow its progress or reverse its  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Edwin M Meyer; James W Simpkins; Jyunji Yamamoto
ISBN: 9781468457278 1468457276 9781468457292 1468457292
OCLC Number: 858918675
Description: 1 online resource.
Contents: Section I. Drugs that Act at Cholinergic Receptors --
A Functionalized Congener Approach to Muscarinic Ligands --
AF102B: A Novel M1 Agonist as a Rational Treatment Strategy in Alzheimer's Disease --
Muscarinic Receptors, Phosphoinositide Hydrolysis and Neuronal Plasticity in the Hippocampus --
Effects of Cholinergic Drugs on Extracellular Levels of Acetylcholine and Choline in Rat Cortex, Hippocampus and Striatum Studied byu Brain Dialysis --
Delayed Matching-to-Sample in Monkeys as a Model for Learning and Memory Deficits: Role of Brain Nicotinic Receptors --
Muscarinic and Nicotinic Receptors in Alzheimer's Disease: Rationale for Cholinergic Drug Treatment --
Section II. CNS-Active Neurotrophic Factors --
Potential Pharmacological Use of Neurotrophic Factors in the Treatment of Neurodegenerative Diseases --
The Use of Reaggregating Cell Cultures and Immortalized Central Nervous System Cells to Study Cholinergic Trophic Mechanisms --
Approaches to Gene Therapy in the CNS: Intracerebral Grafting of Fibroblasts Genetically Modified to Secrete Nerve Growth Factor --
Exogenous Nerve Growth Factor Stimulates Choline Acetyltransferase Activity in Basal Forebrain of Axotomized and Aged Rats --
Neuronotrophic Factors, Gangliosides and Their Interaction: Implications in the Regulation of Nervous System Plasticity --
Suppression of Active Neuronal Death by Immune Interferon --
Basic Fibroblast Growth Factor, an Example of a Multifunctional Trophic Factor with Neurotrophic Activity --
Growth Factor and Lymphokine Effects on Brain Cholinergic Systems --
Metabolic Support of Neural Plasticity: Implications for the Treatment of Alzheimers Disease --
Section III. Additional Novel Treatment Strategies: Improved Brain Delivery, Hormones, and Immunology --
Brain-Enhanced Delivery of Anti-Dementia Drugs --
Development of a Pyrrolidinone Derivative (Cyclic GABA)for Modulating Brain Glutamate Transmission --
A Brain-Enhanced Chemical Delivery System for Gonadal Steroids: Implications for Neurodegenerative Diseases --
Immunologic Approach to Therapy in Alzheimer's Disease --
The Influence of ACTH 4-9 Analog upon Avoidance Learning in Normal and Brain Damaged Rats --
Section IV. Models for Drug-Development: Cholinergic Hypofunction --
Transneuronal Neurochemical and Neuropathological Changes Induced by Nucleus Basalis Lesions: A Possible Degenerative Mechanism in Alzheimer's Disease --
Presynaptic Markers of Cholinergic Function in Cortex Following Ibotenic Acid Lesion of the Basal Forebrain --
Cholinergic-Neuropeptide Y Interactions in the Rat Cerebralcortex: Towards a Model for the Trans-synapticEffects of Cholinergic Transmission --
The Effects of Nucleus Basalis Lesions in the Rat on One Way Passive and Active Avoidance, Two Way Avoidance and Lashly III Maze Learning: An Animal Model for SDAT --
Section V. Models for Drug Development: Other Neurochemical and Behavioral Changes --
NMDA Receptors, Aging and Alzheimer's Disease --
An Excitotoxic Model of Alzheimer's Disease: NMDA Lesions and Initial Neural Grafting Results --
Excitotoxin Mediated Neuronal Loss and the Regulation of Excitatory Amino Acid Release in the Aging Brain --
EEG Power Spectra and Brain Function --
Postmortem Stability of RNA Metabolism in Human Brain: Studies of the Nondemented Conrol and Alzheimer's Disease Cases --
A Model System Demonstrating Parallels in Animal and Human Aging: Extension to Alzheimer's Disease --
Computer-Simulated Everyday Memory Testing for Clinical Trials in Memory Disorders of Aging.
Series Title: Advances in Behavioral Biology, 36; Advances in behavioral biology, 36.
Responsibility: edited by Edwin M. Meyer, James W. Simpkins, Jyunji Yamamoto.

Abstract:

Alzheimer's disease afflicts up to 1 in 5 people over the age of 65 years and causes untold suffering of the patient and their family.  Read more...

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