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Novel inhibitors of leukotrienes

Author: Giancarlo Folco; Bengt Samuelsson; Robert C Murphy
Publisher: Basel ; Boston : Birkhäuser Verlag, ©1999.
Series: PIR (Series)
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

Many new antileukotriene drugs are now marketed as antiasthma drugs and represent the first new drugs in this field since the 1970s.

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Document Type: Book
All Authors / Contributors: Giancarlo Folco; Bengt Samuelsson; Robert C Murphy
ISBN: 376435884X 9783764358846 081765884X 9780817658847
OCLC Number: 41070853
Description: xii, 347 pages : illustrations ; 24 cm.
Contents: 5-Lipoxygenase.- LTC4 synthase: A key enzyme in cysteinyl leukotriene formation.- Leukotriene A4 hydrolase: A key enzyme in chemotactic leukotriene formation.- Metabolism of leukotrienes and formation of new leukotriene structures.- Receptors for cysteinyl-leukotrienes: Targets for new drugs.- Targeted disruption of 5-lipoxygenase.- Transcellular biosynthesis of leukotrienes: A unique mode of cell communication.- Physiological and pathophysiological activities of leukotrienes.- Entry rate and metabolic handling of LTC4 in the human circulation.- Genetic polymorphisms of 5-LO.- Leukotrienes and aspirin-intolerant asthma.- Leukotrienes in nocturnal asthma.- Leukotrienes and allergic asthma.- Inhibitors of leukotrienes: An overview.- The development of zafirlukast (Accolate (R)) and the Zeneca series of peptidyl-leukotriene receptor antagonists.- The development of zileuton (ZYFLO (R)) and the N-hydroxyurea class of 5-lipoxygenase inhibitors.- The development of BAY X 1005 and the Bayer series of leukotriene biosynthesis inhibitors.- The development of iralukast: A member of the Novartis series of cysteinyl leukotriene antagonists.- LTB4 receptor antagonists.- SmithKline Beecham pharmaceuticals' cysteinyl leukotriene receptor antagonists: Pranlukast (SB 205312; Ono-1078; Onon), Pobilukast (SK&F 104353) and SK&F 106203.
Series Title: PIR (Series)
Responsibility: Giancarlo Folco, Bengt Samuelsson, Robert C. Murphy, editors.
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