RT Web Page DB /z-wcorg/ DS http://worldcat.org ID 809794112 LA English UL http://public.eblib.com/choice/publicfullrecord.aspx?p=1030350 T1 Novel synthetic chemistry of ureas and amides A1 Hutchby, Marc., PB Springer PP Berlin; New York YR 2013 SN 9783642320514 3642320511 3642320503 9783642320507 AB In this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation.