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Nucleic Acid Structure : an Introduction

Author: Wilhelm Guschlbauer
Publisher: New York, NY : Springer New York, 1976.
Series: Heidelberg science library.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Teaching a course on nucleic acid structure is a hazardous undertaking, especially if one has no continuous teaching obligations. I still have done it on several occasions in various French universities, when colleagues, suffering from admin­ istrative overwork and excessive teaching obligations, had asked me to do so. This was generally done with a pile of notes and a dozen slides, and I always regretted that no  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wilhelm Guschlbauer
ISBN: 9781461393979 1461393973
OCLC Number: 840283044
Description: 1 online resource.
Contents: 1 Introduction --
1.1 History --
1.2 Cellular localization of nucleic acids --
2 Methods and Techniques --
2.1 Absorption and optical activity (ORD and CD) --
2.2 Nuclear magnetic resonance (NMR) --
2.3 Ultracentrifugation --
2.4 X-ray fiber diffraction --
3 Chemistry and Enzymology of Nucleic Acids --
3.1 Chemistry of nucleic acids and their constituents --
3.2 Chemical reactions of nucleic acids and their constituents --
3.3 Isolation of nucleic acids --
3.4 Degradation and determination of nucleic acids --
4 Structure and Function of DNA --
4.1 The double helix of Watson and Crick --
4.2 Experimental tests of the Watson-Crick hypothesis --
4.3 The role of DNA in the cellular machinery --
the central dogma --
5 Physical Chemistry of DNA --
The Problems of DNA Research --
5.1 Established facts --
5.2 Facts that may require amendments of details of the Watson-Crick theory --
5.3 What do we require from biologically operative DNA? --
5.4 What do we still not know? --
6 Model Systems for Nucleic Acids --
6.1 Polynucleotides --
6.2 Oligonucleotides --
6.3 Association of monomers in solutions and crystals --
7 Errors and Mutations --
7.1 Chemical mutagenesis --
7.2 Base analogues --
7.3 Antibiotics, pigments, dyes --
7.4 Mutagenesis by radiation (UV, X-rays) --
8 The Structure of Ribonucleic Acids --
8.1 Protein biosynthesis --
8.2 Transfer RNA --
8.3 Ribosome structure and rRNA --
8.4 Viral RNA and virus structure --
9 Nucleic Acid --
Protein Interactions --
9.1 Polyamines --
9.2 Polypeptides and protamines --
9.3 Histones and chromatin --
In the Guise of an Epilogue --
Appendix: Abbreviations and Symbols for Nucleic Acids, Polynucleotides, and Their Constituents --
Suggested Bibliography for Advanced Reading.
Series Title: Heidelberg science library.
Responsibility: by Wilhelm Guschlbauer.

Abstract:

Teaching a course on nucleic acid structure is a hazardous undertaking, especially if one has no continuous teaching obligations. Everything changed when, in the spring of 1973, I re- ceived an  Read more...

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