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Nucleic acid structure and recognition

Author: Stephen Neidle
Publisher: Oxford ; New York : Oxford University Press, 2002.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:

This is a comprehensive and clearly presented survey of the field of nucleic acid structure. It covers the major aspects of the structural biology and chemistry of nucleic acids (DNA and RNA), and is  Read more...

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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Stephen Neidle
ISBN: 019850635X 9780198506355
OCLC Number: 49844256
Description: xi, 188 pages : illustrations ; 25 cm
Contents: Ch. 1. Methods for studying nucleic acid structure --
1.1. Introduction --
1.2. X-ray diffraction methods for structural analysis --
1.3. NMR methods for studying nucleic acid structure and dynamics --
1.4. Molecular modelling and simulation of nucleic acids --
1.5. Chemical and enzymatic probes of structure --
1.6. Sources of structural data --
Ch. 2. The building-blocks of DNA and RNA --
2.1. Introduction --
2.2. Base pairing --
2.3. Base and base pair flexibility --
2.4. Sugar puckers --
2.5. Conformations about the glycosidic blood --
2.6. The backbone torsion angles and correlated flexibility --
Ch. 3. DNA structure as observed in fibres and crystals --
3.1. Structural fundamentals --
3.2. Polynucleotide structures from fibre diffraction studies --
3.3. B-DNA oligonucleotide structure as seen in crystallographic analyses --
3.4. A-DNA oligonucleotide crystal structures --
3.5. Z-DNA --
left-handed DNA --
3.6. Bent DNA --
3.7. Concluding remarks --
Ch. 4. DNA-DNA recognition: non-standard and higher order DNA structures --
4.1. Mismatches in DNA --
4.2. DNA triple helices --
4.3. Guanine quadruplexes --
4.4. DNA junctions --
Ch. 5. Principles of small molecule-DNA recognition --
5.1. Introduction --
5.2. DNA-water interactions --
5.3. General features of DNA-drug and small-molecule recognition --
5.4. Intercalative binding --
5.5. Intercalative-type binding to higher order DNAs --
5.6. Groove binding molecules --
5.7. Covalent bonding --
Ch. 6. The RNA structural world --
6.1. Introduction --
6.2. Fundamentals of RNA structure --
6.3. Transfer RNA Structures --
6.4. Ribozymes --
6.5. The ribosome, a ribozyme machine --
6.6. RNA motifs --
Ch. 7. Principles of protein-DNA recognition --
7.1. Introduction --
7.2. Direct protein-DNA contacts --
7.3. Major-groove interactions --
the [alpha]-helix as the recognition element --
7.4. Zinc-finger recognition modes --
7.5. Other major-groove recognition motifs --
7.6. Minor-groove recognition --
7.7. DNA bending and protein recognition.
Responsibility: Stephen Neidle.
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... this book includes a short and readable description, and the webpage gives quick access to the ribosome coordinate files for an awesome molecular experience ... let me congratulate Steve on Read more...

 
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