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Nucleic Acid Switches and Sensors

Author: Scott K Silverman
Publisher: Boston, MA : Springer-Verlag US, 2006. ©2006
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and  Read more...
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Genre/Form: Electronic resource
Electronic books
Additional Physical Format: Print version:
Silverman, Scott.
Nucleic Acid Switches and Sensors.
Dordrecht : Springer, ©2010
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Scott K Silverman
ISBN: 9780387472577 0387472576 128325056X 9781283250566
OCLC Number: 767213297
Description: 1 online resource (ix, 125 pages) : digital
Contents: Artificial Nucleic Acid Switches and Sensors --
Allosteric Ribozymes as Molecular Switches and Sensors --
Ribozymes and Deoxyribozymes Switched by Oligonucleotides --
Ribozymes Switched by Proteins --
Fluorescence-Signaling Nucleic Acid-Based Sensors --
Natural Nucleic Acid Switches and Sensors --
Protein-Induced RNA Switches in Nature --
Riboswitches as Genetic Control Elements --
Switchable RNA Motifs as Drug Targets.
Responsibility: by Scott K. Silverman.

Abstract:

In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.

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