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Nucleic acids as molecular diagnostics

Author: Andreas Keller; Eckart Meese
Publisher: Weinheim, Germany : Wiley-VCH, [2015] ©2015
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
By integrating technology, supporting infrastructure and efficient application, this all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Nucleic acids as molecular diagnostics.
Weinheim, Germany : Wiley-VCH, ©2015
xx, 369 pages
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Andreas Keller; Eckart Meese
ISBN: 9783527672233 3527672230 9783527672226 3527672222 9783527672219 3527672214 9783527672165 3527672168 3527335560 9783527335565
OCLC Number: 890801490
Notes: Title from PDF title page (viewed on Sept. 18, 2014).
Description: 1 online resource
Contents: Nucleic Acids as Molecular Diagnostics; Contents; List of Contributors; Preface; 1 Next-Generation Sequencing for Clinical Diagnostics of Cardiomyopathies; 1.1 Introduction; 1.2 Cardiomyopathies and Why Genetic Testing is Needed; 1.3 NGS; 1.4 NGS for Cardiomyopathies; 1.5 Sample Preparation; 1.6 Bioinformatics Analysis Pipeline; 1.7 Interpretation of Results and Translation into Clinical Practice; References; 2 MicroRNAs as Novel Biomarkers in Cardiovascular Medicine; 2.1 Introduction; 2.2 miRNAs are Associated with Cardiovascular Risk Factors; 2.3 miRNAs in Coronary Artery Disease. 2.4 miRNAs in Cardiac Ischemia and Necrosis2.5 miRNAs as Biomarkers of Heart Failure; 2.6 Future Challenges; Acknowledgments; References; 3 MicroRNAs in Primary Brain Tumors: Functional Impact and Potential Use for Diagnostic Purposes; 3.1 Background; 3.2 Gliomas; 3.2.1 miRNA as Biomarkers in Glioma Tissue; 3.2.2 Circulating miRNA as Biomarkers; 3.3 Meningiomas; 3.4 Pituitary Adenomas; 3.5 Medulloblastomas; 3.6 Other Brain Tumors; 3.6.1 Schwannomas; 3.6.2 PCNSLs; 3.7 Summary and Outlook; References; 4 Genetic and Epigenetic Alterations in Sporadic Colorectal Cancer: Clinical Implications. 4.1 Introduction4.2 Chromosomal Instability; 4.3 Microsatellite Instability; 4.4 Driver Somatic Mutations in CRC; 4.4.1 APC; 4.4.2 TP53; 4.4.3 KRAS; 4.4.4 BRAF; 4.4.5 PIK3CA; 4.4.6 Other Mutations; 4.5 Epigenetic Instability in CRC; 4.6 Hypomethylation; 4.7 CpG Island Methylator Phenotype; 4.8 Concluding Remarks; References; 5 Nucleic Acid-Based Markers in Urologic Malignancies; 5.1 Introduction; 5.2 Bladder Cancer; 5.2.1 Hereditary Factors for Bladder Cancer; 5.2.2 Single Nucleotide Polymorphisms; 5.2.3 RNA Alterations in Bladder Cancer; 5.2.3.1 FGFR3 Pathway; 5.2.3.2 p53 Pathway. 5.2.3.3 Urine-Based Markers5.2.3.4 Serum-Based Markers; 5.2.4 Sporadic Factors for Bladder Cancer; 5.2.5 Genetic Changes in Non-Invasive Papillary Urothelial Carcinoma; 5.2.5.1 FGFR 3; 5.2.5.2 Changes in the Phosphatidylinositol 3-Kinase Pathway; 5.2.6 Genetic Changes in Muscle-Invasive Urothelial Carcinoma; 5.2.6.1 TP53, RB, and Cell Cycle Control Genes; 5.2.6.2 Other Genomic Alterations; 5.2.7 Genetic Alterations with Unrecognized Associations to Tumor Stage and Grade; 5.2.7.1 Alterations of Chromosome 9; 5.2.7.2 RAS Gene Mutations; 5.3 Prostate Cancer. 5.3.1 Hereditary Factors for Prostate Cancer5.3.2 Sporadic Factors for Prostate Cancer; 5.3.2.1 PSA and Other Protein Markers; 5.3.2.2 Nucleic Acid Biomarkers; 5.3.3 Prostate Cancer: Summary; 5.4 Renal Cell Carcinoma; 5.4.1 Hereditary Factors for RCC; 5.4.2 Sporadic Factors for RCC; 5.4.2.1 The Old; 5.4.2.2 The New; 5.5 Summary; References; 6 From the Genetic Make-Up to the Molecular Signature of Non-Coding RNA in Breast Cancer; 6.1 Introduction; 6.2 Molecular Breast Cancer Detection; 6.2.1 Circulating Free DNA; 6.2.2 Long Intergenic Non-Coding RNA; 6.2.2.1 HOTAIR; 6.2.2.2 H19; 6.2.2.3 GAS5.
Responsibility: edited by Andreas Keller and Eckart Meese.

Abstract:

By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical  Read more...

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