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Nucleoside mimetics : their chemistry and biological properties

Author: Claire Simons
Publisher: Amsterdam : Gordon and Breach Science Publishers, ©2001.
Series: Advanced chemistry texts, v. 3.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

An introduction to the chemistry of nucleoside mimetics which combines carbohydrate, heterocyclic and asymmetric synthesis, this text provides an insight into the diversity of nucleosides, the range  Read more...

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Document Type: Book
All Authors / Contributors: Claire Simons
ISBN: 9789056993245 9056993240
OCLC Number: 46831031
Description: ix, 191 pages : illustrations ; 26 cm.
Contents: Structure of Nucleosides --
Structure of the Sugar Moiety --
Structure of the Heterocyclic Base Moiety --
Nucleoside Conformation --
Glycosyl Link Geometry --
C4'-C5' Bond Geometry --
Ring Puckering --
Nomenclature --
Spectroscopy --
Mass Spectroscopy --
NMR Spectroscopy --
Biological Properties --
RNA and DNA --
Purine and Pyrimidine Nucleotide Biosynthesis --
Mechanisms of Action of Nucleoside Mimetics --
Inhibitors Targeted at Reverse Transcriptase --
Inhibitors Targeted at DNA Viruses --
Inhibitors Targeted at Nucleotide Metabolising Enzymes --
Synthesis of Conventional D-Nucleosides --
First Syntheses of the Natural Ribonucleosides --
Stereospecificity in Nucleoside Synthesis --
Coupling Methods --
Coupling of Heterocyclic Salts with Halo-Sugars --
Vorbruggen Procedure --
Nucleoside Synthesis from Glycals --
Glycosylamine Procedure --
Enzymatic Synthesis --
Sugar Modifications --
Sugar Modifications via Anhydronucleosides --
Sugar Modifications via Epoxides --
Deoxygenation --
Azido and Amino Sugars --
Halogenation --
2'- and 3'-C-Nucleosides --
Heterocyclic Base Modifications --
Pyrimidine Modifications --
Purine Modifications --
Sugar Modified Nucleosides --
Isonucleosides --
2'-Isonucleosides --
3'-Isonucleosides --
4'-Substituted Nucleosides --
4'-Thinoucleosides --
4'-Aza-nucleosides --
Dioxo-, Oxathio- and Dithio-Nucleosides --
Oxaza-, Isoxa- and Thiaza-Nucleosides --
Ring Size --
Oxetanocin-A and Derivatives --
Pyranose Nucleosides --
Spiro-Nucleosides --
Heterocyclic Base Modified Nucleosides.
Series Title: Advanced chemistry texts, v. 3.
Responsibility: Claire Simons.
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"This book provides an overview with insights in to nucleosides mimetics . [It] will enhance research and academic library collections on biochemical and medicinal chemistry subjects." - E-Streams, Read more...

 
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