skip to content
Oligomerization and allosteric modulation in G-protein coupled receptors Preview this item
ClosePreview this item
Checking...

Oligomerization and allosteric modulation in G-protein coupled receptors

Author: Terrence P Kenakin
Publisher: Oxford : Academic Press, 2013.
Series: Progress in molecular biology and translational science, v. 115.
Edition/Format:   eBook : Document : English : 1st edView all editions and formats
Summary:
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Additional Physical Format: Print version:
Kenakin, Terry.
Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors.
San Diego : Elsevier Science, ©2013
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Terrence P Kenakin
ISBN: 9780123947918 012394791X
OCLC Number: 834598601
Description: 1 online resource (xiii, 471 pages, [8] pages of plates :) : illustrations (some color).
Contents: Front cover; Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors; Copyright; Contents; Contributors; Preface; Chapter One: Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors; 1. Introduction; 2. General Considerations for Assays Designed to Identify and Characterize Allosteric Modulators; 3. General Workflow Used in Identifying and Characterizing Allosteric Modulators; 3.1. High-throughput screening; 3.2. Potency determinations; 3.3. Efficacy determinations; 4. Data Analysis: General Features for Allosteric Interactions. 5. Kinetic Assays to Measure Allosteric Interactions at 7TMRs5.1. Fluorescence-based second-messenger assays; 5.2. Calcium mobilization, general principles; 5.3. Thallium flux, general principles; 5.4. Fluorescent probe methodology; 5.5. Alternatives to fluorescence technology; 6. Label-Free Technology; 7. Endpoint Assays; 7.1. cAMP accumulation; 7.2. PI hydrolysis; 7.3. ERK1/2 phosphorylation; 7.4. Arrestin recruitment; 7.5. Transcriptional regulation; 8. Radioligand Binding Assays for Allosteric Interactions; 8.1. General methodology and initial considerations; 8.1.1. Receptor source. 8.1.2. Choice of radioligand8.1.3. Experimental conditions; 9. Competitive or Not Competitive; 9.1. Allosteric radioligand competition; 9.2. Orthosteric radioligand competition; 9.3. Dissociation kinetic assays; 10. Conclusions and Future Directions; Acknowledgments; References; Chapter Two: Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Pote ... ; 1. Introduction; 2. Physiology and Pharmacology of mGlus; 2.1. Advantages and complexities of allosteric modulation; 3. Allosteric Modulation of mGlus. 3.1. Quantification of allosteric modulation3.2. Verification of an allosteric mechanism of action; 4. Location of Allosteric Sites; 4.1. Structural features of mGlus; 4.2. Localization of allosteric binding sites; 4.3. Common allosteric sites within and between subtypes; 4.4. Multiple allosteric sites within a receptor subtype; 5. Therapeutic Indications for Allosteric Modulators; 5.1. mGlu1 NAMs for neuropathic pain; 5.2. mGlu2/3 PAMs and agonists for schizophrenia and cognition; 5.3. mGlu2/3 in anxiety; 5.4. mGlu2/3 PAMs for drug abuse; 5.5. mGlu2/3 PAMs for depression. 5.6. mGlu4 PAMs for PD and neuroprotection5.7. mGlu4 PAMs in pain and neuroinflammation; 5.8. mGlu5 NAMs for anxiety; 5.9. mGlu5 NAMs for major depression disorder; 5.10. mGlu5 NAMs for Autism; 5.11. mGlu5 NAMs for drug abuse; 5.12. mGlu5 NAMs for potential treatment of astrocytic disorders; 5.13. mGlu5 for treatment of PD, iatrogenic dystonias, gastroesophogeal reflux disorder, and migraine; 5.14. mGlu5 PAMs for schizophrenia and cognition; 5.15. mGlu5 PAMs for treatment of TSC; 5.16. mGlu7 for stress and anxiety; 5.17. mGlu8 potential for the treatment of PD and anxiety.
Series Title: Progress in molecular biology and translational science, v. 115.
Responsibility: edited by Terry Kenakin.

Abstract:

Reflects on developments and research surrounding G protein-coupled receptors. This title includes chapters that cover a large breadth of research, including GPCR role in stem cell function and  Read more...

Reviews

Editorial reviews

Publisher Synopsis

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in Read more...

 
User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/834598601> # Oligomerization and allosteric modulation in G-protein coupled receptors
    a schema:MediaObject, schema:Book, schema:CreativeWork ;
   library:oclcnum "834598601" ;
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/enk> ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/1210455588#Place/oxford> ; # Oxford
   schema:about <http://dewey.info/class/572.696/e23/> ;
   schema:about <http://id.worldcat.org/fast/936832> ; # G proteins--Receptors
   schema:about <http://id.worldcat.org/fast/805690> ; # Allosteric regulation
   schema:about <http://experiment.worldcat.org/entity/work/data/1210455588#Topic/science_life_sciences_biochemistry> ; # SCIENCE--Life Sciences--Biochemistry
   schema:about <http://experiment.worldcat.org/entity/work/data/1210455588#Topic/g_proteins_receptors> ; # G proteins--Receptors
   schema:bookEdition "1st ed." ;
   schema:bookFormat schema:EBook ;
   schema:contributor <http://viaf.org/viaf/19854231> ; # Terrence P. Kenakin
   schema:datePublished "2013" ;
   schema:description "In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Key features: * Contributions from leading authorities * Informs an."@en ;
   schema:description "Front cover; Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors; Copyright; Contents; Contributors; Preface; Chapter One: Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors; 1. Introduction; 2. General Considerations for Assays Designed to Identify and Characterize Allosteric Modulators; 3. General Workflow Used in Identifying and Characterizing Allosteric Modulators; 3.1. High-throughput screening; 3.2. Potency determinations; 3.3. Efficacy determinations; 4. Data Analysis: General Features for Allosteric Interactions."@en ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/1210455588> ;
   schema:genre "Electronic books"@en ;
   schema:inLanguage "en" ;
   schema:isPartOf <http://worldcat.org/issn/1877-1173> ; # Progress in molecular biology and translational science ;
   schema:isSimilarTo <http://worldcat.org/entity/work/data/1210455588#CreativeWork/oligomerization_and_allosteric_modulation_in_g_protein_coupled_receptors> ;
   schema:name "Oligomerization and allosteric modulation in G-protein coupled receptors"@en ;
   schema:productID "834598601" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/834598601#PublicationEvent/oxford_academic_press_2013> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/1210455588#Agent/academic_press> ; # Academic Press
   schema:url <http://www.sciencedirect.com/science/book/9780123945877> ;
   schema:url <http://site.ebrary.com/id/10657177> ;
   schema:url <http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=541239> ;
   schema:url <http://www.sciencedirect.com/science/bookseries/18771173/115> ;
   schema:url <http://public.eblib.com/choice/publicfullrecord.aspx?p=1125293> ;
   schema:workExample <http://worldcat.org/isbn/9780123947918> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/834598601> ;
    .


Related Entities

<http://experiment.worldcat.org/entity/work/data/1210455588#Topic/science_life_sciences_biochemistry> # SCIENCE--Life Sciences--Biochemistry
    a schema:Intangible ;
   schema:name "SCIENCE--Life Sciences--Biochemistry"@en ;
    .

<http://id.worldcat.org/fast/805690> # Allosteric regulation
    a schema:Intangible ;
   schema:name "Allosteric regulation"@en ;
    .

<http://id.worldcat.org/fast/936832> # G proteins--Receptors
    a schema:Intangible ;
   schema:name "G proteins--Receptors"@en ;
    .

<http://viaf.org/viaf/19854231> # Terrence P. Kenakin
    a schema:Person ;
   schema:familyName "Kenakin" ;
   schema:givenName "Terrence P." ;
   schema:name "Terrence P. Kenakin" ;
    .

<http://worldcat.org/entity/work/data/1210455588#CreativeWork/oligomerization_and_allosteric_modulation_in_g_protein_coupled_receptors>
    a schema:CreativeWork ;
   rdfs:label "Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors." ;
   schema:description "Print version:" ;
   schema:isSimilarTo <http://www.worldcat.org/oclc/834598601> ; # Oligomerization and allosteric modulation in G-protein coupled receptors
    .

<http://worldcat.org/isbn/9780123947918>
    a schema:ProductModel ;
   schema:isbn "012394791X" ;
   schema:isbn "9780123947918" ;
    .

<http://worldcat.org/issn/1877-1173> # Progress in molecular biology and translational science ;
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/834598601> ; # Oligomerization and allosteric modulation in G-protein coupled receptors
   schema:issn "1877-1173" ;
   schema:name "Progress in molecular biology and translational science ;" ;
   schema:name "Progress in molecular biology and translational science," ;
    .

<http://www.sciencedirect.com/science/bookseries/18771173/115>
   rdfs:comment "(Unlimited Concurrent Users)" ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.