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Oncogenes meet metabolism : from deregulated genes to a broader understanding of tumour physiology

Author: Guido Kroemer
Publisher: Berlin ; New York : Springer, ©2008.
Series: Ernst Schering Foundation symposium proceedings, 2007/4.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
In 1920s, Otto Warburg described the phenomenon of a aerobic glycolysisa (TM), the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburga (TM)s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Oncogenes meet metabolism.
Berlin ; New York : Springer, ©2008
(DLC) 2008925641
(OCoLC)293319991
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Guido Kroemer
ISBN: 9783540794776 3540794778 9783540794783 3540794786
OCLC Number: 302054329
Description: 1 online resource (xv, 264 pages) : illustrations.
Contents: Mitochondria and Cancer; Role of the Metabolic Stress Responses of Apoptosis and Autophagy in Tumor Suppression; The Interplay Between MYC and HIF in the Warburg Effect; Using Metabolomics to Monitor Anticancer Drugs; Biomarker Discovery for Drug Development and Translational Medicine Using Metabonomics; Pyruvate Kinase Type M2: A Key Regulator Within the Tumour Metabolome and a Tool for Metabolic Profiling of Tumours; Molecular Imaging of Tumor Metabolism and Apoptosis; Minimally Invasive Biomarkers for Therapy Monitoring; Use of Metabolic Pathway Flux Information in Anticancer Drug Design.
Series Title: Ernst Schering Foundation symposium proceedings, 2007/4.
Responsibility: G. Kroemer [and others], editors.

Abstract:

In 1920s, Otto Warburg described the phenomenon of `aerobic glycolysis', the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions.  Read more...

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