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Oncoimmunology : a practical guide for cancer immunotherapy

Author: L Zitvogel; Guido Kroemer
Publisher: Cham, Switzerland : Springer, 2018.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: L Zitvogel; Guido Kroemer
ISBN: 9783319624310 3319624318 331962430X 9783319624303
OCLC Number: 1015372139
Description: 1 online resource
Contents: Fundamental bases: Immunology for the non immunologist: Cellular and molecular bases of cancer immunosurveillance.- Innate immunity/NK in cancer immunosurveillance.- Biology of regulatory T cells.- Adenosine, P2R receptors.-Plasmacytoid DC dysfunctions in cancer.- Chemotherapy and MDSC.- Biology of Myeloid Derived Suppressor Cells.- T cell fitness/polarization for antitumor immune responses.- Tumor associated antigens and neoantigens.- Tumor associated antigens and neoantigens.- Immunization with peptides.- Immunogenic cell death and chemotherapy.- Breakthrough or advanced status of approaches: Cancer vaccines in HPV malignancies.- Innate sensing of tumors and TLR agonists.- DC-based cancer vaccines in melanoma.- DC-based vaccines in breast cancer.- T cell-based immunotherapies : CAR-T and TCR engineered T cells.-IDO and TDO-based inhibition in cancer. - FDA-EMA approval of I-O: Tumor-specific antibodies.- Anti-CTLA4 Abs.- Bispecific anti-CD3xCD19 antibodies.- Combination of ICB in MM.- Oncolytic viruses.- Bacillus Calmette-Guerin and mycobacterial cell wall nucleic acid complexes in the treatment of non-muscle-invasive bladder cancer .- The immunoscore.- PDL-1 and other immunological diagnosis tools.- Developping fields: The development of anti-41BB, Lag3, Anti-OX40, anti-ICOS, anti-GITR Ab.- mRNA-based vaccination.- Links between tumor genetics and immunotherapy.- Local immunotherapies of cancer.- Preventive DC-based cancer vaccines.- Gut microbiota/oncomicrobiotics in cancer therapeutics.- Strategies to reduce intratumoral Treg.- Cold versus hot tumors.- Immunopathology : an emerging field.- Changes in Clinical Practice: Side effects of I-O.- The clinical armamentarium in melanoma.- The clinical armamentarium in kidney cancers.- The clinical armamentarium in lung cancers.- The clinical armamentarium in prostate cancers.- Challenges of O-I for breast, ovarian, and non MSI colon cancers.- Challenges in colon cancers.- Current status of O-I in hematologic malignancies.- Glioma and I-O.- Assessing affinity and avidity of TCRs.- Immunomonitoring studies.
Responsibility: Laurence Zitvogel, Guido Kroemer, editors.

Abstract:

In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their  Read more...

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"This is an excellent book on a topic that currently represents a major therapeutic approach in oncology. Written by leading experts, the book is truly an invaluable resource for anyone interested in Read more...

 
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