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Optimizing the "drug-like" properties of leads in drug discovery

Author: Ronald T Borchardt; American Association of Pharmaceutical Scientists.
Publisher: New York, NY : Springer, ©2006.
Series: Biotechnology (Arlington, Va.), v. 4.
Edition/Format:   Print book : CD for computer : Document : Conference publication   Computer File : EnglishView all editions and formats
Summary:

This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in  Read more...

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Genre/Form: Congresses
Material Type: Conference publication, Document, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Ronald T Borchardt; American Association of Pharmaceutical Scientists.
ISBN: 9780387340562 0387340564
OCLC Number: 84717629
Description: x, 512 pages : illustrations (some color) ; 27 cm + 1 CD-ROM (4 3/4).
Contents: Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds --
Role Of Mechanistic Transport Studies in Lead Optimization --
Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions --
Case-History- Use of ADME Studies for Optimization of Drug Candidates --
Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization --
Lipid Based Systems, Drug and Lead Optimization --
Biopharmaceutics Modeling and the Role of Dose Formulation on Oral Exposure --
Application of Physiochemical Data to Support Lead Optimization by Discovery --
Computational Models Supporting Lead Optimization in Drug Discovery --
Prodrug Strategies for Improving Drug-Like Properties --
The Application of Multivariate Data Analysis to Compound Property Optimization --
Case History: Toxicology biomarker development using Toxicogenomics --
Predicting Idiosyncratic Drug Reactions --
Elementary Predictive Toxicology for Advanced Applications --
The Application of PK/PD Modeling and Simulations During Lead Optimization --
Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization --
Optimization Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development --
The Relevance of Transporters in Determining Drug Disposition.
Series Title: Biotechnology (Arlington, Va.), v. 4.
Responsibility: Ronald T. Borchardt [and others], editors.
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